Chloride/phosphate ratio in primary hyperparathyroidism

Judy C Boughey, C. J. Ewart, M. J. Yost, J. M. Nottingham, J. J. Brown

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The chloride/phosphate (Cl:PO 4) ratio is known to help distinguish between the hypercalcemia of primary hyperparathyroidism (HPT) and hypercalcemia from other causes. The Cl:PO 4 ratio of 106 patients with surgically proven primary HPT was compared with that of 126 normocalcemic healthy outpatients to examine its usefulness as a confirmatory test for primary HPT. The Cl:PO 4 ratio was significantly higher in patients with HPT (42.5 ± 7.0) compared with healthy controls (28.7 ± 4.6). Patients with HPT and mild renal insufficiency (serum creatinine, 1.5-2.4 mg/dL) also showed a significant increase in the Cl:PO 4 ratio (37.3 ± 6.6) as did those with HPT with borderline elevations in serum calcium (calcium <11; Cl:PO 4, 40.3 ± 5.6). A Cl:PO 4 ratio ≥ 33 is a reliable diagnostic test for primary HPT when compared with a normal population. The Cl:PO 4 ratio is also of value in the evaluation of the patient with suspected HPT and borderline calcium elevation and those with mild renal impairment. These data suggest that an inexpensive Cl:PO 4 ratio might replace serum parathormone assay as a confirmatory test in the evaluation of suspected primary HPT, especially for those patients in whom a localizing study (sestamibi scan) is obtained before neck exploration.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalAmerican Surgeon
Volume70
Issue number1
StatePublished - 2004
Externally publishedYes

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Primary Hyperparathyroidism
Hyperparathyroidism
Chlorides
Phosphates
Hypercalcemia
Calcium
Serum
Parathyroid Hormone
Routine Diagnostic Tests
Renal Insufficiency
Creatinine
Outpatients
Neck
Kidney
Population

ASJC Scopus subject areas

  • Surgery

Cite this

Boughey, J. C., Ewart, C. J., Yost, M. J., Nottingham, J. M., & Brown, J. J. (2004). Chloride/phosphate ratio in primary hyperparathyroidism. American Surgeon, 70(1), 25-28.

Chloride/phosphate ratio in primary hyperparathyroidism. / Boughey, Judy C; Ewart, C. J.; Yost, M. J.; Nottingham, J. M.; Brown, J. J.

In: American Surgeon, Vol. 70, No. 1, 2004, p. 25-28.

Research output: Contribution to journalArticle

Boughey, JC, Ewart, CJ, Yost, MJ, Nottingham, JM & Brown, JJ 2004, 'Chloride/phosphate ratio in primary hyperparathyroidism', American Surgeon, vol. 70, no. 1, pp. 25-28.
Boughey JC, Ewart CJ, Yost MJ, Nottingham JM, Brown JJ. Chloride/phosphate ratio in primary hyperparathyroidism. American Surgeon. 2004;70(1):25-28.
Boughey, Judy C ; Ewart, C. J. ; Yost, M. J. ; Nottingham, J. M. ; Brown, J. J. / Chloride/phosphate ratio in primary hyperparathyroidism. In: American Surgeon. 2004 ; Vol. 70, No. 1. pp. 25-28.
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