Chemotherapy-induced skin toxicity and capillary leak syndrome

Manrup K. Hunjan, Somaira Nowsheen, Alvaro J. Ramos-Rodriguez, Alina G. Bridges, Julia Lehman, Shahrukh K. Hashmi, Rokea A. el-Azhary

Research output: Contribution to journalReview article

1 Scopus citations


Background: The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS. Methods: Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Results: Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical-pathologic confirmation. Conclusions: Although TEC is generally self-limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.

Original languageEnglish (US)
JournalInternational journal of dermatology
StatePublished - Jan 1 2019


ASJC Scopus subject areas

  • Dermatology

Cite this

Hunjan, M. K., Nowsheen, S., Ramos-Rodriguez, A. J., Bridges, A. G., Lehman, J., Hashmi, S. K., & el-Azhary, R. A. (2019). Chemotherapy-induced skin toxicity and capillary leak syndrome. International journal of dermatology.