Chemotherapy-induced skin toxicity and capillary leak syndrome

Manrup K. Hunjan; Somaira Nowsheen; Alvaro J. Ramos-Rodriguez; Alina G. Bridges; Julia S. Lehman; Shahrukh K. Hashmi; Rokea A. el-Azhary

doi:10.1111/ijd.14392

Chemotherapy-induced skin toxicity and capillary leak syndrome

Manrup K. Hunjan, Somaira Nowsheen, Alvaro J. Ramos-Rodriguez, Alina G. Bridges, Julia S. Lehman, Shahrukh K. Hashmi, Rokea A. el-Azhary

Dermatology

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2 Scopus citations

Abstract

Background: The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS. Methods: Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Results: Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical-pathologic confirmation. Conclusions: Although TEC is generally self-limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.

Original language	English (US)
Pages (from-to)	856-860
Number of pages	5
Journal	International journal of dermatology
Volume	58
Issue number	7
DOIs	https://doi.org/10.1111/ijd.14392
State	Published - Jul 2019

ASJC Scopus subject areas

Dermatology

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10.1111/ijd.14392

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title = "Chemotherapy-induced skin toxicity and capillary leak syndrome",

abstract = "Background: The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS. Methods: Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Results: Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical-pathologic confirmation. Conclusions: Although TEC is generally self-limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.",

author = "Hunjan, {Manrup K.} and Somaira Nowsheen and Ramos-Rodriguez, {Alvaro J.} and Bridges, {Alina G.} and Lehman, {Julia S.} and Hashmi, {Shahrukh K.} and el-Azhary, {Rokea A.}",

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year = "2019",

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doi = "10.1111/ijd.14392",

language = "English (US)",

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TY - JOUR

T1 - Chemotherapy-induced skin toxicity and capillary leak syndrome

AU - Hunjan, Manrup K.

AU - Nowsheen, Somaira

AU - Ramos-Rodriguez, Alvaro J.

AU - Bridges, Alina G.

AU - Lehman, Julia S.

AU - Hashmi, Shahrukh K.

AU - el-Azhary, Rokea A.

PY - 2019/7

Y1 - 2019/7

N2 - Background: The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS. Methods: Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Results: Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical-pathologic confirmation. Conclusions: Although TEC is generally self-limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.

AB - Background: The occurrence of chemotherapy-related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS. Methods: Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS. Results: Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical-pathologic confirmation. Conclusions: Although TEC is generally self-limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.

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Chemotherapy-induced skin toxicity and capillary leak syndrome

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