Chemoprevention in barrett's esophagus

Sumera Ilyas; Cathrine J. Demars; Navtej S. Buttar

doi:10.1007/s12029-007-9006-7

Chemoprevention in barrett's esophagus

Sumera Ilyas, Cathrine J. Demars, Navtej S. Buttar

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Barrett's metaplasia-associated esophageal adenocarcinoma is one of the most rapidly increasing cancers in Western countries. Whereas early detection remains the cornerstone of prevention, chemoprevention is emerging as a complementary strategy. Carcinogenesis in Barrett's mucosa is a multistep process in which cellular growth becomes progressively dysregulated. Fortunately, the process of carcinogenesis is a protracted one, which provides ample opportunity for intervention. In this review, we will discuss various potential chemoprevention targets and rationale behind their use to prevent Barrett's related esophageal adenocarcinoma. We will also critically appraise the emerging preclinical and clinical literature regarding prevention of neoplasia in Barrett's esophagus.

Original language	English (US)
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of gastrointestinal cancer
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s12029-007-9006-7
State	Published - Jan 2007

Keywords

Adenocarcinoma of esophagus
Barrett's esophagus
Carcinogenesis
Chemoprevention
Signaling

ASJC Scopus subject areas

Oncology
Gastroenterology

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10.1007/s12029-007-9006-7

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AB - Barrett's metaplasia-associated esophageal adenocarcinoma is one of the most rapidly increasing cancers in Western countries. Whereas early detection remains the cornerstone of prevention, chemoprevention is emerging as a complementary strategy. Carcinogenesis in Barrett's mucosa is a multistep process in which cellular growth becomes progressively dysregulated. Fortunately, the process of carcinogenesis is a protracted one, which provides ample opportunity for intervention. In this review, we will discuss various potential chemoprevention targets and rationale behind their use to prevent Barrett's related esophageal adenocarcinoma. We will also critically appraise the emerging preclinical and clinical literature regarding prevention of neoplasia in Barrett's esophagus.

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KW - Signaling

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Chemoprevention in barrett's esophagus

Abstract

Keywords

ASJC Scopus subject areas

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