Chemoprevention in barrett's esophagus

Sumera Ilyas, Cathrine J. Demars, Navtej S. Buttar

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Barrett's metaplasia-associated esophageal adenocarcinoma is one of the most rapidly increasing cancers in Western countries. Whereas early detection remains the cornerstone of prevention, chemoprevention is emerging as a complementary strategy. Carcinogenesis in Barrett's mucosa is a multistep process in which cellular growth becomes progressively dysregulated. Fortunately, the process of carcinogenesis is a protracted one, which provides ample opportunity for intervention. In this review, we will discuss various potential chemoprevention targets and rationale behind their use to prevent Barrett's related esophageal adenocarcinoma. We will also critically appraise the emerging preclinical and clinical literature regarding prevention of neoplasia in Barrett's esophagus.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of gastrointestinal cancer
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • Adenocarcinoma of esophagus
  • Barrett's esophagus
  • Carcinogenesis
  • Chemoprevention
  • Signaling

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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