Abstract
There is considerable confusion concerning the mechanism of lymphocyte death during HIV infection. During the course of HIV infection, M-tropic viruses (R5) that use CCR5 chemokine coreceptors frequently evolve to T-tropic viruses (X4) that use CXCR4 receptors. In this study we show that activation of the CD4 or CCR5 receptor by R5 HIVenv causes a caspase 8-dependent death of both uninfected and infected CD4 T cells. In contrast, CXCR4 activation by X4 HIVenv induces a caspase-independent death of both uninfected CD4 and CD8 T cells and infected CD4 cells. These results suggest that activation of the chemokine receptor by HIVenv determines the mechanism of death for both infected and uninfected T lymphocytes.
Original language | English (US) |
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Pages (from-to) | 207-215 |
Number of pages | 9 |
Journal | Journal of Clinical Investigation |
Volume | 107 |
Issue number | 2 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- General Medicine