Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes

Stacey R. Vlahakis, Alicia Algeciras-Schimnich, German Bou, Carrie J. Heppelmann, Angelina Villasis-Keever, Ronald G. Collman, Carlos V. Paya

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

There is considerable confusion concerning the mechanism of lymphocyte death during HIV infection. During the course of HIV infection, M-tropic viruses (R5) that use CCR5 chemokine coreceptors frequently evolve to T-tropic viruses (X4) that use CXCR4 receptors. In this study we show that activation of the CD4 or CCR5 receptor by R5 HIVenv causes a caspase 8-dependent death of both uninfected and infected CD4 T cells. In contrast, CXCR4 activation by X4 HIVenv induces a caspase-independent death of both uninfected CD4 and CD8 T cells and infected CD4 cells. These results suggest that activation of the chemokine receptor by HIVenv determines the mechanism of death for both infected and uninfected T lymphocytes.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalJournal of Clinical Investigation
Volume107
Issue number2
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes'. Together they form a unique fingerprint.

Cite this