Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording

LongJun Wu, Xiangyao Li, Tao Chen, Ming Ren, Min Zhuo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The anterior cingulate cortex (ACC) is involved in sensory, cognitive, and executive functions. Studies of synaptic transmission and plasticity in the ACC provide an understanding of basic cellular and molecular mechanisms for brain functions. Previous anatomic studies suggest complex local interactions among neurons within the ACC. However, there is a lack of functional studies of such synaptic connections between ACC neurons. In the present study, we characterized the neuronal connections in the superficial layers (I-III) of the mouse ACC using dual whole-cell patch clamp recording technique. Four types of synaptic connections were observed, which are from a pyramidal neuron to a pyramidal neuron, from a pyramidal neuron to an interneuron, from an interneuron to a pyramidal neuron and from an interneuron to an interneuron. These connections exist among neurons in layer II/III or between neurons located layer I and II/III, respectively. Moreover, reciprocal connections exist in all four types of paired neurons. Our results provide the first key evidence of functional excitatory and inhibitory connections in the ACC.

Original languageEnglish (US)
Article number32
JournalMolecular Brain
Volume2
Issue number1
DOIs
StatePublished - Nov 30 2009
Externally publishedYes

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Gyrus Cinguli
Pyramidal Cells
Interneurons
Neurons
Neuronal Plasticity
Executive Function
Patch-Clamp Techniques
Synaptic Transmission
Cognition
Brain

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. / Wu, LongJun; Li, Xiangyao; Chen, Tao; Ren, Ming; Zhuo, Min.

In: Molecular Brain, Vol. 2, No. 1, 32, 30.11.2009.

Research output: Contribution to journalArticle

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