Characterization and evaluation of inversion algorithms for MR elastography

Armando Manduca, Travis E. Oliphant, David S. Lake, M. Alex Dresner, Richard Lorne Ehman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

Magnetic resonance elastography (MRE) can visualize and measure acoustic shear waves in tissue-tike materials subjected to harmonic mechanical excitation. This allows the calculation of local values of material parameters such as shear modulus and attenuation. Various inversion algorithms to perform such calculations have been proposed. Under certain assumptions (discussed in detail), the problem reduces to local inversion of the Helmholtz equation. Three algorithms are considered to perform this inversion: Direct Inversion, Local Frequency Estimation, and Matched Filter. To study the noise sensitivity, resolution, and accuracy of these techniques, studies were conducted on synthetic and physical phantoms and on in-vivo breast data. All three algorithms accurately reconstruct shear modulus, demarcate differences between tissues, and identify tumors as areas of higher stiffness, but they vary in noise sensitivity and resolution. The Matched Filter, designed for optimal behavior in noise, provides the best combination of sharpness and smoothness. Challenges remain in pulse sequence design, delivering sufficient signal to certain areas of the body, and improvements in processing algorithms, but MRE shows great potential for non-invasive in vivo determination of mechanical properties.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsM. Sonka, J. Michael Fitzpatrick
Pages1180-1185
Number of pages6
Volume4684 II
DOIs
StatePublished - 2002
EventMedical Imaging 2002: Image Processing - San Diego, CA, United States
Duration: Feb 24 2002Feb 28 2002

Other

OtherMedical Imaging 2002: Image Processing
CountryUnited States
CitySan Diego, CA
Period2/24/022/28/02

Fingerprint

inversions
matched filters
evaluation
Matched filters
Magnetic resonance
magnetic resonance
Elastic moduli
Tissue
shear
Frequency estimation
Helmholtz equation
Helmholtz equations
Shear waves
sharpness
breast
S waves
Tumors
stiffness
tumors
attenuation

Keywords

  • Elastography
  • Inversion
  • MRE
  • MRI
  • Reconstruction
  • Shear modulus
  • Stiffness

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Manduca, A., Oliphant, T. E., Lake, D. S., Dresner, M. A., & Ehman, R. L. (2002). Characterization and evaluation of inversion algorithms for MR elastography. In M. Sonka, & J. Michael Fitzpatrick (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4684 II, pp. 1180-1185) https://doi.org/10.1117/12.467076

Characterization and evaluation of inversion algorithms for MR elastography. / Manduca, Armando; Oliphant, Travis E.; Lake, David S.; Dresner, M. Alex; Ehman, Richard Lorne.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / M. Sonka; J. Michael Fitzpatrick. Vol. 4684 II 2002. p. 1180-1185.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Manduca, A, Oliphant, TE, Lake, DS, Dresner, MA & Ehman, RL 2002, Characterization and evaluation of inversion algorithms for MR elastography. in M Sonka & J Michael Fitzpatrick (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4684 II, pp. 1180-1185, Medical Imaging 2002: Image Processing, San Diego, CA, United States, 2/24/02. https://doi.org/10.1117/12.467076
Manduca A, Oliphant TE, Lake DS, Dresner MA, Ehman RL. Characterization and evaluation of inversion algorithms for MR elastography. In Sonka M, Michael Fitzpatrick J, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4684 II. 2002. p. 1180-1185 https://doi.org/10.1117/12.467076
Manduca, Armando ; Oliphant, Travis E. ; Lake, David S. ; Dresner, M. Alex ; Ehman, Richard Lorne. / Characterization and evaluation of inversion algorithms for MR elastography. Proceedings of SPIE - The International Society for Optical Engineering. editor / M. Sonka ; J. Michael Fitzpatrick. Vol. 4684 II 2002. pp. 1180-1185
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