Characteristics of luteinizing hormone secretion in younger versus older premenopausal women

D. W. Matt, S. W. Kauma, S. M. Pincus, Johannes D Veldhuis, W. S. Evans

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

OBJECTIVES: The objectives of this study were to document specific attributes of pulsatile luteinizing hormone secretion in middle-aged women before discernible alterations in their menstrual cycles and to compare the results to corresponding data obtained in younger women. STUDY DESIGN: After documenting normal cycle length, biphasic basal body temperatures, and normal midluteal progesterone in younger and middle-aged women during an initial cycle, daily blood samples and samples withdrawn at 10-minute intervals for 8 hours during the midfollicular phase were obtained during a subsequent cycle. RESULTS: Assessment of luteinizing hormone pulses with the pulse detection algorithm Cluster demonstrated a prolonged interpulse interval and increased pulse width in the older women. Assessment of luteinizing hormone secretory bursts and half-life with the deconvolution analysis procedure demonstrated a prolonged interburst interval and half-life in the older women. Appraisal of approximate entropy revealed greater orderliness of luteinizing hormone release in the older women. CONCLUSIONS: Middle-aged women exhibit alterations in hypothalamic-pituitary function that may account in part for age-related changes in reproductive potential.

Original languageEnglish (US)
Pages (from-to)504-510
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume178
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Luteinizing Hormone
Half-Life
Entropy
Menstrual Cycle
Body Temperature
Progesterone

Keywords

  • Aging
  • Fecundity
  • Luteinizing hormone secretion

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Characteristics of luteinizing hormone secretion in younger versus older premenopausal women. / Matt, D. W.; Kauma, S. W.; Pincus, S. M.; Veldhuis, Johannes D; Evans, W. S.

In: American Journal of Obstetrics and Gynecology, Vol. 178, No. 3, 1998, p. 504-510.

Research output: Contribution to journalArticle

Matt, D. W. ; Kauma, S. W. ; Pincus, S. M. ; Veldhuis, Johannes D ; Evans, W. S. / Characteristics of luteinizing hormone secretion in younger versus older premenopausal women. In: American Journal of Obstetrics and Gynecology. 1998 ; Vol. 178, No. 3. pp. 504-510.
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