Characteristics of cutaneous marginal zone lymphomas with marked plasmacytic differentiation and a T cell-rich background

Julia Turbiner Geyer, Judith A. Ferry, Janina A. Longtine, Thomas J. Flotte, Nancy L. Harris, Lawrence R. Zukerberg

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Primary cutaneous marginal zone lymphoma (MZL) is a common B-cell lymphoma of skin and is characterized by an infiltrate of neoplastic marginal zone B cells typically within the marginal zones of reactive lymphoid follicles and the interfollicular region. However, in our experience, many cases have underemphasized features such as marked plasmacytic differentiation and/or a prominent T-cell component, which may obscure the neoplastic B cells and lead to misdiagnosis. We wanted to draw attention to these features and have studied 15 cases of MZL with marked plasmacytic differentiation, 10 of which had numerous T cells, some with cytologic atypia, and few B cells in the interfollicular region. Plasma cells were monotypic in all cases by in situ hybridization. By polymerase chain reaction, 6 of 8 T cell-rich cases had an IGH gene rearrangement, and none were clonal for T-cell receptor gene. We discuss the terminology, morphologic features, molecular profile, behavior, and differential diagnosis of cutaneous MZL.

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalAmerican journal of clinical pathology
Volume133
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • IgH rearrangement
  • Marginal zone lymphoma
  • Plasmacytic differentiation
  • Skin
  • T-cell predominance

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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