Characteristics of cutaneous marginal zone lymphomas with marked plasmacytic differentiation and a T cell-rich background

Julia Turbiner Geyer, Judith A. Ferry, Janina A. Longtine, Thomas J Flotte, Nancy L. Harris, Lawrence R. Zukerberg

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Primary cutaneous marginal zone lymphoma (MZL) is a common B-cell lymphoma of skin and is characterized by an infiltrate of neoplastic marginal zone B cells typically within the marginal zones of reactive lymphoid follicles and the interfollicular region. However, in our experience, many cases have underemphasized features such as marked plasmacytic differentiation and/or a prominent T-cell component, which may obscure the neoplastic B cells and lead to misdiagnosis. We wanted to draw attention to these features and have studied 15 cases of MZL with marked plasmacytic differentiation, 10 of which had numerous T cells, some with cytologic atypia, and few B cells in the interfollicular region. Plasma cells were monotypic in all cases by in situ hybridization. By polymerase chain reaction, 6 of 8 T cell-rich cases had an IGH gene rearrangement, and none were clonal for T-cell receptor gene. We discuss the terminology, morphologic features, molecular profile, behavior, and differential diagnosis of cutaneous MZL.

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalAmerican Journal of Clinical Pathology
Volume133
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Lymphoma
B-Lymphocytes
T-Lymphocytes
Skin
T-Cell Receptor Genes
Gene Rearrangement
B-Cell Lymphoma
Cellular Structures
Plasma Cells
Diagnostic Errors
Terminology
In Situ Hybridization
Differential Diagnosis
Polymerase Chain Reaction

Keywords

  • IgH rearrangement
  • Marginal zone lymphoma
  • Plasmacytic differentiation
  • Skin
  • T-cell predominance

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Characteristics of cutaneous marginal zone lymphomas with marked plasmacytic differentiation and a T cell-rich background. / Geyer, Julia Turbiner; Ferry, Judith A.; Longtine, Janina A.; Flotte, Thomas J; Harris, Nancy L.; Zukerberg, Lawrence R.

In: American Journal of Clinical Pathology, Vol. 133, No. 1, 01.2010, p. 59-69.

Research output: Contribution to journalArticle

Geyer, Julia Turbiner ; Ferry, Judith A. ; Longtine, Janina A. ; Flotte, Thomas J ; Harris, Nancy L. ; Zukerberg, Lawrence R. / Characteristics of cutaneous marginal zone lymphomas with marked plasmacytic differentiation and a T cell-rich background. In: American Journal of Clinical Pathology. 2010 ; Vol. 133, No. 1. pp. 59-69.
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