Chaperones in neurodegeneration

Iris Lindberg, James Shorter, R. Luke Wiseman, Fabrizio Chiti, Chad A. Dickey, Pamela J McLean

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Cellular protein homeostasis (proteostasis) maintains the integrity of the proteome and includes protein synthesis, folding, oligomerization, and turnover; chaperone proteins assist with all of these processes. Neurons appear to be especially susceptible to failures in proteostasis, and this is now increasingly recognized as a major origin of neurodegenerative disease. This review, based on a minisymposium presented at the 2015 Society for Neuroscience meeting, describes new work in the area of neuronal proteostasis, with a specific focus on the roles and therapeutic uses of protein chaperones. We first present a brief review of protein misfolding and aggregation in neurodegenerative disease. We then discuss different aspects of chaperone control of neuronal proteostasis on topics ranging from chaperone engineering, to chaperone-mediated blockade of protein oligomerization and cytotoxicity, to the potential rescue of neurodegenerative processes using modified chaperone proteins.

Original languageEnglish (US)
Pages (from-to)13853-13859
Number of pages7
JournalJournal of Neuroscience
Volume35
Issue number41
DOIs
StatePublished - Oct 14 2015

Fingerprint

Proteins
Homeostasis
Neurodegenerative Diseases
Protein Folding
Therapeutic Uses
Proteome
Neurons

Keywords

  • Chaperone
  • Heat shock proteins
  • Neurodegeneration
  • Parkinson’s disease
  • Protein misfolding
  • Proteostasis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lindberg, I., Shorter, J., Wiseman, R. L., Chiti, F., Dickey, C. A., & McLean, P. J. (2015). Chaperones in neurodegeneration. Journal of Neuroscience, 35(41), 13853-13859. https://doi.org/10.1523/JNEUROSCI.2600-15.2015

Chaperones in neurodegeneration. / Lindberg, Iris; Shorter, James; Wiseman, R. Luke; Chiti, Fabrizio; Dickey, Chad A.; McLean, Pamela J.

In: Journal of Neuroscience, Vol. 35, No. 41, 14.10.2015, p. 13853-13859.

Research output: Contribution to journalArticle

Lindberg, I, Shorter, J, Wiseman, RL, Chiti, F, Dickey, CA & McLean, PJ 2015, 'Chaperones in neurodegeneration', Journal of Neuroscience, vol. 35, no. 41, pp. 13853-13859. https://doi.org/10.1523/JNEUROSCI.2600-15.2015
Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Chaperones in neurodegeneration. Journal of Neuroscience. 2015 Oct 14;35(41):13853-13859. https://doi.org/10.1523/JNEUROSCI.2600-15.2015
Lindberg, Iris ; Shorter, James ; Wiseman, R. Luke ; Chiti, Fabrizio ; Dickey, Chad A. ; McLean, Pamela J. / Chaperones in neurodegeneration. In: Journal of Neuroscience. 2015 ; Vol. 35, No. 41. pp. 13853-13859.
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