Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: Longitudinal MRI study

Dennis Chan, John C. Janssen, Jennifer Lynn Whitwell, Hilary C. Watt, Rhian Jenkins, Chris Frost, Martin N. Rossor, Nick C. Fox

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

The extent to which cerebral atrophy in Alzheimer's disease changes with time is unknown. We used multiple MRI scans to measure progression of cerebral atrophy in 12 patients with Alzheimer's disease who were followed up from a presymptomatic stage through to moderately severe dementia. Analysis with hierarchical regression models with quadratic terms in time provided evidence of increasing yearly percentage losses in brain volume. At the time when patients were judged to have mild dementia (mini-mental state examination score MMSE=23), mean yearly loss of brain volume was 2·8% (95% CI 2·3-3·3), which rose by 0·32% per year (0· 15-0·50). Our findings reinforce the need for early diagnosis and therapeutic intervention in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)1121-1122
Number of pages2
JournalLancet
Volume362
Issue number9390
DOIs
StatePublished - Oct 4 2003
Externally publishedYes

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Atrophy
Longitudinal Studies
Alzheimer Disease
Dementia
Brain
Early Diagnosis
Magnetic Resonance Imaging
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease : Longitudinal MRI study. / Chan, Dennis; Janssen, John C.; Whitwell, Jennifer Lynn; Watt, Hilary C.; Jenkins, Rhian; Frost, Chris; Rossor, Martin N.; Fox, Nick C.

In: Lancet, Vol. 362, No. 9390, 04.10.2003, p. 1121-1122.

Research output: Contribution to journalArticle

Chan, D, Janssen, JC, Whitwell, JL, Watt, HC, Jenkins, R, Frost, C, Rossor, MN & Fox, NC 2003, 'Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: Longitudinal MRI study', Lancet, vol. 362, no. 9390, pp. 1121-1122. https://doi.org/10.1016/S0140-6736(03)14469-8
Chan, Dennis ; Janssen, John C. ; Whitwell, Jennifer Lynn ; Watt, Hilary C. ; Jenkins, Rhian ; Frost, Chris ; Rossor, Martin N. ; Fox, Nick C. / Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease : Longitudinal MRI study. In: Lancet. 2003 ; Vol. 362, No. 9390. pp. 1121-1122.
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