TY - JOUR
T1 - Challenging and complex decisions in the management of the BRCA mutation carrier
AU - Stan, Daniela L.
AU - Shuster, Lynne T.
AU - Wick, Myra J.
AU - Swanson, Casey L.
AU - Pruthi, Sandhya
AU - Bakkum-Gamez, Jamie N.
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Women afflicted by the hereditary breast and ovarian cancer syndrome face complex decisions regarding medical interventions aimed at reducing their risk of ovarian and breast cancer, interventions which in turn may interfere with their fertility and cause early menopause. This review addresses selected topics of importance and controversy in the management of the BRCA mutation carrier, such as psychological well-being and quality of life, breast and ovarian cancer screening, risk-reducing interventions for breast cancer and ovarian cancer, the issue of hysterectomy at the time of the risk-reducing salpingo-oophorectomy, health consequences of early surgical menopause, and safety of hormonal therapy after oophorectomy. The information presented is based on an extensive review of the literature on the selected topics and on the expertise of our multidisciplinary team.
AB - Women afflicted by the hereditary breast and ovarian cancer syndrome face complex decisions regarding medical interventions aimed at reducing their risk of ovarian and breast cancer, interventions which in turn may interfere with their fertility and cause early menopause. This review addresses selected topics of importance and controversy in the management of the BRCA mutation carrier, such as psychological well-being and quality of life, breast and ovarian cancer screening, risk-reducing interventions for breast cancer and ovarian cancer, the issue of hysterectomy at the time of the risk-reducing salpingo-oophorectomy, health consequences of early surgical menopause, and safety of hormonal therapy after oophorectomy. The information presented is based on an extensive review of the literature on the selected topics and on the expertise of our multidisciplinary team.
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U2 - 10.1089/jwh.2013.4407
DO - 10.1089/jwh.2013.4407
M3 - Review article
C2 - 23987739
AN - SCOPUS:84885073951
SN - 1540-9996
VL - 22
SP - 825
EP - 834
JO - Journal of Women's Health
JF - Journal of Women's Health
IS - 10
ER -