CFTR, a channel with the structure of a transporter

John R. Riordan; Xiu-Bao D Chang

CFTR, a channel with the structure of a transporter

John R. Riordan, Xiu-Bao D Chang

Research output: Contribution to journal › Article › peer-review

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to a superfamily of active transport molecules. However, when expressed in a wide variety of heterologous cell systems and when purified to homogeneity and reconstituted in planar lipid bilayers, it exhibits low conductance chloride channel activity. We postulate that the active transport capability of the molecule has been adapted to provide very stringent metabolic control of this channel which is responsible for chloride secretion and hydration of wet epithelial surfaces.

Original language	English (US)
Pages (from-to)	221-222
Number of pages	2
Journal	BBA - Bioenergetics
Volume	1101
Issue number	2
State	Published - Jul 17 1992
Externally published	Yes

Keywords

Cystic fibrosis
Cystic fibrosis transmembrane conductance regulator
Membrane transport

ASJC Scopus subject areas

Biophysics

Cite this

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N2 - The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to a superfamily of active transport molecules. However, when expressed in a wide variety of heterologous cell systems and when purified to homogeneity and reconstituted in planar lipid bilayers, it exhibits low conductance chloride channel activity. We postulate that the active transport capability of the molecule has been adapted to provide very stringent metabolic control of this channel which is responsible for chloride secretion and hydration of wet epithelial surfaces.

AB - The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to a superfamily of active transport molecules. However, when expressed in a wide variety of heterologous cell systems and when purified to homogeneity and reconstituted in planar lipid bilayers, it exhibits low conductance chloride channel activity. We postulate that the active transport capability of the molecule has been adapted to provide very stringent metabolic control of this channel which is responsible for chloride secretion and hydration of wet epithelial surfaces.

KW - Cystic fibrosis

KW - Cystic fibrosis transmembrane conductance regulator

KW - Membrane transport

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CFTR, a channel with the structure of a transporter

Abstract

Keywords

ASJC Scopus subject areas

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