Cervical HPV DNA detection as a predictor of a recurrent SIL diagnosis among untreated women

Philip E. Castle, Tamara R. Zemlo, Robert D. Burk, David R. Scott, Mark E. Sherman, Attila T. Lorincz, Robert J. Kurman, Andrew G. Glass, Brenda B. Rush, Kai Li Liaw, Mark Schiffman

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objectives. This study was conducted to test whether patient history of untreated cervical intraepithelial neoplasia (CIN) 1 or low-grade squamous intraepithelial lesions (LGSIL) modifies the interpretation of a positive HPV DNA result with regards to subsequent squamous intraepithelial lesions (SIL). Methods. Seventy-three women with recurrent SIL were compared to 105 controls who remain cytologically normal during follow up. Cervical samples collected at enrollment were assayed for HPV DNA in the subject and control groups. Results. Women with and without a history of LGSIL who tested positive for HPV DNA were at a similarly increased risk of having (recurrent) LGSIL as compared to controls. However, in women with a history of LGSIL, HPV DNA appeared to be less predictive for high-grade squamous intraepithelial lesions (HGSIL) than in women without a history of disease. Conclusions. Past history of untreated CIN1 or LGSIL does not modify the predictive value of a positive HPV DNA test for subsequent LGSIL. The observed difference of the predictive value of a positive HPV DNA test for the risk of recurrent HSIL compared to incident HSIL should be pursued.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalJournal of Lower Genital Tract Disease
Volume5
Issue number3
DOIs
StatePublished - Dec 27 2001

Keywords

  • HPV DNA testing
  • Pap smear screening
  • Recurrent S.I.L.

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Castle, P. E., Zemlo, T. R., Burk, R. D., Scott, D. R., Sherman, M. E., Lorincz, A. T., Kurman, R. J., Glass, A. G., Rush, B. B., Liaw, K. L., & Schiffman, M. (2001). Cervical HPV DNA detection as a predictor of a recurrent SIL diagnosis among untreated women. Journal of Lower Genital Tract Disease, 5(3), 138-143. https://doi.org/10.1046/j.1526-0976.2001.53005.x