Cerebrovascular accident in patients with giant cell arteritis: A systematic review and meta-analysis of cohort studies

Patompong Ungprasert, Karn Wijarnpreecha, Matthew Koster, Charat Thongprayoon, Kenneth J Warrington

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objectives To investigate the risk of cerebrovascular accident (CVA) among patients with giant cell arteritis (GCA). Methods We conducted a systematic review and meta-analysis of cohort studies that reported relative risks, hazard ratios, or standardized incidence ratios comparing CVA risk in patients with GCA versus non-GCA comparators. Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results Eight studies with 17,919 patients with GCA were identified and included in our data analysis. The pooled risk ratio of CVA in patients with GCA versus non-GCA controls was 1.40 (95% CI: 1.27–1.56). The statistical heterogeneity was low with an I2 of 31%. Conclusions Our study indicates a significantly increased risk of CVA among patients with GCA.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalSeminars in Arthritis and Rheumatism
Volume46
Issue number3
DOIs
StatePublished - Dec 1 2016

Keywords

  • Cerebrovascular accident
  • Giant cell arteritis
  • Meta-analysis

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

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