TY - JOUR
T1 - Cerebrovascular accident in patients with giant cell arteritis
T2 - A systematic review and meta-analysis of cohort studies
AU - Ungprasert, Patompong
AU - Wijarnpreecha, Karn
AU - Koster, Matthew J.
AU - Thongprayoon, Charat
AU - Warrington, Kenneth J.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Objectives To investigate the risk of cerebrovascular accident (CVA) among patients with giant cell arteritis (GCA). Methods We conducted a systematic review and meta-analysis of cohort studies that reported relative risks, hazard ratios, or standardized incidence ratios comparing CVA risk in patients with GCA versus non-GCA comparators. Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results Eight studies with 17,919 patients with GCA were identified and included in our data analysis. The pooled risk ratio of CVA in patients with GCA versus non-GCA controls was 1.40 (95% CI: 1.27–1.56). The statistical heterogeneity was low with an I2 of 31%. Conclusions Our study indicates a significantly increased risk of CVA among patients with GCA.
AB - Objectives To investigate the risk of cerebrovascular accident (CVA) among patients with giant cell arteritis (GCA). Methods We conducted a systematic review and meta-analysis of cohort studies that reported relative risks, hazard ratios, or standardized incidence ratios comparing CVA risk in patients with GCA versus non-GCA comparators. Pooled risk ratio and 95% confidence interval were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results Eight studies with 17,919 patients with GCA were identified and included in our data analysis. The pooled risk ratio of CVA in patients with GCA versus non-GCA controls was 1.40 (95% CI: 1.27–1.56). The statistical heterogeneity was low with an I2 of 31%. Conclusions Our study indicates a significantly increased risk of CVA among patients with GCA.
KW - Cerebrovascular accident
KW - Giant cell arteritis
KW - Meta-analysis
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U2 - 10.1016/j.semarthrit.2016.07.005
DO - 10.1016/j.semarthrit.2016.07.005
M3 - Article
C2 - 27546492
AN - SCOPUS:84995960033
SN - 0049-0172
VL - 46
SP - 361
EP - 366
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 3
ER -