Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome

Eric Thouvenot, Geoffrey Hinsinger, Christophe Demattei, Ugur Uygunoglu, Giovanni Castelnovo, Sophie Pittion-Vouyovitch, Darin Okuda, Orhun H Kantarci, Daniel Pelletier, Sylvain Lehmann, Philippe Marin, Aksel Siva, Christine Lebrun

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal
DOIs
StateAccepted/In press - Mar 1 2018

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Relapsing-Remitting Multiple Sclerosis
Cerebrospinal Fluid
Spinal Cord
Chitinase-3-Like Protein 1
Oligoclonal Bands
Immunoglobulin G

Keywords

  • biomarkers
  • cerebrospinal fluid
  • diagnosis
  • Multiple sclerosis
  • prognosis
  • radiologically isolated syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome. / Thouvenot, Eric; Hinsinger, Geoffrey; Demattei, Christophe; Uygunoglu, Ugur; Castelnovo, Giovanni; Pittion-Vouyovitch, Sophie; Okuda, Darin; Kantarci, Orhun H; Pelletier, Daniel; Lehmann, Sylvain; Marin, Philippe; Siva, Aksel; Lebrun, Christine.

In: Multiple Sclerosis Journal, 01.03.2018.

Research output: Contribution to journalArticle

Thouvenot, E, Hinsinger, G, Demattei, C, Uygunoglu, U, Castelnovo, G, Pittion-Vouyovitch, S, Okuda, D, Kantarci, OH, Pelletier, D, Lehmann, S, Marin, P, Siva, A & Lebrun, C 2018, 'Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome', Multiple Sclerosis Journal. https://doi.org/10.1177/1352458518767043
Thouvenot, Eric ; Hinsinger, Geoffrey ; Demattei, Christophe ; Uygunoglu, Ugur ; Castelnovo, Giovanni ; Pittion-Vouyovitch, Sophie ; Okuda, Darin ; Kantarci, Orhun H ; Pelletier, Daniel ; Lehmann, Sylvain ; Marin, Philippe ; Siva, Aksel ; Lebrun, Christine. / Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome. In: Multiple Sclerosis Journal. 2018.
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abstract = "Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.",
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AU - Thouvenot, Eric

AU - Hinsinger, Geoffrey

AU - Demattei, Christophe

AU - Uygunoglu, Ugur

AU - Castelnovo, Giovanni

AU - Pittion-Vouyovitch, Sophie

AU - Okuda, Darin

AU - Kantarci, Orhun H

AU - Pelletier, Daniel

AU - Lehmann, Sylvain

AU - Marin, Philippe

AU - Siva, Aksel

AU - Lebrun, Christine

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.

AB - Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.

KW - biomarkers

KW - cerebrospinal fluid

KW - diagnosis

KW - Multiple sclerosis

KW - prognosis

KW - radiologically isolated syndrome

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