Cerebral microbleeds

Prevalence and relationship to amyloid burden

Jonathan Graff-Radford, Hugo Botha, Alejandro Rabinstein, Jeffrey L. Gunter, Scott A. Przybelski, Timothy Lesnick, John III Huston, Kelly D. Flemming, Gregory M. Preboske, Matthew L. Senjem, Robert D Jr. Brown, Michelle M Mielke, Rosebud O Roberts, Val Lowe, David S Knopman, Ronald Carl Petersen, Walter K Kremers, Prashanthi D Vemuri, Clifford R Jr. Jack, Kejal M Kantarci

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To describe the prevalence of cerebral microbleeds (CMBs) and determine the association between CMBs and β-amyloid burden on PET. METHODS: From the population-based Mayo Clinic Study of Aging, 1,215 participants (53% male) underwent 3-tesla MRI scans with T2* gradient recalled echo sequences from October 2011 to February 2017. A total of 1,123 participants (92%) underwent 11C-Pittsburgh compound B (PiB)-PET scans. The prevalence of CMBs was derived by adjusting for nonparticipation and standardizing to the Olmsted County, MN, population. The relationship between β-amyloid burden and CMB presence and location was tested using logistic regression models. Ordinal logistic models tested the relationship between CMB frequency and β-amyloid burden. RESULTS: Two hundred seventy-four participants (22.6%) had at least one CMB. CMB frequency increased with age by decade (11% aged 60-69 years, 22% 70-79 years, and 39% 80 years and older). After adjusting for age, sex, and hypertension, PiB standardized uptake value ratio (SUVR) was associated with increased odds of a CMB. The association between PiB SUVR and CMBs was location-specific; PiB SUVR was associated with lobar CMBs but not deep CMBs. Age, hypertension, and PiB SUVR were associated with increasing CMB count. CMB density was greatest in parietal and occipital regions; β-amyloid burden correlated with concentration of CMBs in all lobar regions. Among participants with multiple CMBs, greater PiB uptake occurred in the pre- and postcentral gyri superiorly, the superior parietal lobe and precuneus, the angular gyrus, inferior temporal gyrus, and temporal poles. CONCLUSIONS: The prevalence of CMBs increases with age. In this population-based sample, β-amyloid load was associated with lobar but not with deep CMBs.

Original languageEnglish (US)
Pages (from-to)e253-e262
JournalNeurology
Volume92
Issue number3
DOIs
StatePublished - Jan 15 2019

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Amyloid
Parietal Lobe
Logistic Models
Population
Hypertension
Occipital Lobe
Somatosensory Cortex
Temporal Lobe
Positron-Emission Tomography
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Cerebral microbleeds : Prevalence and relationship to amyloid burden. / Graff-Radford, Jonathan; Botha, Hugo; Rabinstein, Alejandro; Gunter, Jeffrey L.; Przybelski, Scott A.; Lesnick, Timothy; Huston, John III; Flemming, Kelly D.; Preboske, Gregory M.; Senjem, Matthew L.; Brown, Robert D Jr.; Mielke, Michelle M; Roberts, Rosebud O; Lowe, Val; Knopman, David S; Petersen, Ronald Carl; Kremers, Walter K; Vemuri, Prashanthi D; Jack, Clifford R Jr.; Kantarci, Kejal M.

In: Neurology, Vol. 92, No. 3, 15.01.2019, p. e253-e262.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To describe the prevalence of cerebral microbleeds (CMBs) and determine the association between CMBs and β-amyloid burden on PET. METHODS: From the population-based Mayo Clinic Study of Aging, 1,215 participants (53{\%} male) underwent 3-tesla MRI scans with T2* gradient recalled echo sequences from October 2011 to February 2017. A total of 1,123 participants (92{\%}) underwent 11C-Pittsburgh compound B (PiB)-PET scans. The prevalence of CMBs was derived by adjusting for nonparticipation and standardizing to the Olmsted County, MN, population. The relationship between β-amyloid burden and CMB presence and location was tested using logistic regression models. Ordinal logistic models tested the relationship between CMB frequency and β-amyloid burden. RESULTS: Two hundred seventy-four participants (22.6{\%}) had at least one CMB. CMB frequency increased with age by decade (11{\%} aged 60-69 years, 22{\%} 70-79 years, and 39{\%} 80 years and older). After adjusting for age, sex, and hypertension, PiB standardized uptake value ratio (SUVR) was associated with increased odds of a CMB. The association between PiB SUVR and CMBs was location-specific; PiB SUVR was associated with lobar CMBs but not deep CMBs. Age, hypertension, and PiB SUVR were associated with increasing CMB count. CMB density was greatest in parietal and occipital regions; β-amyloid burden correlated with concentration of CMBs in all lobar regions. Among participants with multiple CMBs, greater PiB uptake occurred in the pre- and postcentral gyri superiorly, the superior parietal lobe and precuneus, the angular gyrus, inferior temporal gyrus, and temporal poles. CONCLUSIONS: The prevalence of CMBs increases with age. In this population-based sample, β-amyloid load was associated with lobar but not with deep CMBs.",
author = "Jonathan Graff-Radford and Hugo Botha and Alejandro Rabinstein and Gunter, {Jeffrey L.} and Przybelski, {Scott A.} and Timothy Lesnick and Huston, {John III} and Flemming, {Kelly D.} and Preboske, {Gregory M.} and Senjem, {Matthew L.} and Brown, {Robert D Jr.} and Mielke, {Michelle M} and Roberts, {Rosebud O} and Val Lowe and Knopman, {David S} and Petersen, {Ronald Carl} and Kremers, {Walter K} and Vemuri, {Prashanthi D} and Jack, {Clifford R Jr.} and Kantarci, {Kejal M}",
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T2 - Prevalence and relationship to amyloid burden

AU - Graff-Radford, Jonathan

AU - Botha, Hugo

AU - Rabinstein, Alejandro

AU - Gunter, Jeffrey L.

AU - Przybelski, Scott A.

AU - Lesnick, Timothy

AU - Huston, John III

AU - Flemming, Kelly D.

AU - Preboske, Gregory M.

AU - Senjem, Matthew L.

AU - Brown, Robert D Jr.

AU - Mielke, Michelle M

AU - Roberts, Rosebud O

AU - Lowe, Val

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Kremers, Walter K

AU - Vemuri, Prashanthi D

AU - Jack, Clifford R Jr.

AU - Kantarci, Kejal M

PY - 2019/1/15

Y1 - 2019/1/15

N2 - OBJECTIVE: To describe the prevalence of cerebral microbleeds (CMBs) and determine the association between CMBs and β-amyloid burden on PET. METHODS: From the population-based Mayo Clinic Study of Aging, 1,215 participants (53% male) underwent 3-tesla MRI scans with T2* gradient recalled echo sequences from October 2011 to February 2017. A total of 1,123 participants (92%) underwent 11C-Pittsburgh compound B (PiB)-PET scans. The prevalence of CMBs was derived by adjusting for nonparticipation and standardizing to the Olmsted County, MN, population. The relationship between β-amyloid burden and CMB presence and location was tested using logistic regression models. Ordinal logistic models tested the relationship between CMB frequency and β-amyloid burden. RESULTS: Two hundred seventy-four participants (22.6%) had at least one CMB. CMB frequency increased with age by decade (11% aged 60-69 years, 22% 70-79 years, and 39% 80 years and older). After adjusting for age, sex, and hypertension, PiB standardized uptake value ratio (SUVR) was associated with increased odds of a CMB. The association between PiB SUVR and CMBs was location-specific; PiB SUVR was associated with lobar CMBs but not deep CMBs. Age, hypertension, and PiB SUVR were associated with increasing CMB count. CMB density was greatest in parietal and occipital regions; β-amyloid burden correlated with concentration of CMBs in all lobar regions. Among participants with multiple CMBs, greater PiB uptake occurred in the pre- and postcentral gyri superiorly, the superior parietal lobe and precuneus, the angular gyrus, inferior temporal gyrus, and temporal poles. CONCLUSIONS: The prevalence of CMBs increases with age. In this population-based sample, β-amyloid load was associated with lobar but not with deep CMBs.

AB - OBJECTIVE: To describe the prevalence of cerebral microbleeds (CMBs) and determine the association between CMBs and β-amyloid burden on PET. METHODS: From the population-based Mayo Clinic Study of Aging, 1,215 participants (53% male) underwent 3-tesla MRI scans with T2* gradient recalled echo sequences from October 2011 to February 2017. A total of 1,123 participants (92%) underwent 11C-Pittsburgh compound B (PiB)-PET scans. The prevalence of CMBs was derived by adjusting for nonparticipation and standardizing to the Olmsted County, MN, population. The relationship between β-amyloid burden and CMB presence and location was tested using logistic regression models. Ordinal logistic models tested the relationship between CMB frequency and β-amyloid burden. RESULTS: Two hundred seventy-four participants (22.6%) had at least one CMB. CMB frequency increased with age by decade (11% aged 60-69 years, 22% 70-79 years, and 39% 80 years and older). After adjusting for age, sex, and hypertension, PiB standardized uptake value ratio (SUVR) was associated with increased odds of a CMB. The association between PiB SUVR and CMBs was location-specific; PiB SUVR was associated with lobar CMBs but not deep CMBs. Age, hypertension, and PiB SUVR were associated with increasing CMB count. CMB density was greatest in parietal and occipital regions; β-amyloid burden correlated with concentration of CMBs in all lobar regions. Among participants with multiple CMBs, greater PiB uptake occurred in the pre- and postcentral gyri superiorly, the superior parietal lobe and precuneus, the angular gyrus, inferior temporal gyrus, and temporal poles. CONCLUSIONS: The prevalence of CMBs increases with age. In this population-based sample, β-amyloid load was associated with lobar but not with deep CMBs.

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