TY - JOUR
T1 - Cerebral granular cell tumor
T2 - Immunohistochemical and electron microscopic study
AU - Dickson, Dennis W.
AU - Suzuki, Kinuko I.
AU - Kanner, Ronald
AU - Weitz, Stephen
AU - Horoupian, Dikran S.
PY - 1986/5
Y1 - 1986/5
N2 - A rare intracerebral granular cell tumor (GCT) was studied by immu-nocytochemical and ultrastructural methods. The tumor was composed of two cell types-filament-rich and granular cells. Granular cells contained PAS-positive, dia-stase-resistant granules that ultrastructurally corresponded to autophagic cytosegre-somes. Glial fibrillary acidic protein, the intermediate filament protein specific for astrocytes, was demonstrated in the filament-rich and, to a lesser extent, in the granular cells. Unlike noncerebral GCT, neither S-100 protein nor vimentin was detected in the tumor cells. On the other hand, both cerebral and noncerebral GCT were labeled immunocytochemically with peanut lectin (Arachis hypogaea). The results suggest that cerebral GCT share some features with noncerebral GCT, but differ in other respects. They further suggest that GCT may be derived from different cell types depending on the tissue of origin, and that cerebral GCT may be derived from astrocytes.
AB - A rare intracerebral granular cell tumor (GCT) was studied by immu-nocytochemical and ultrastructural methods. The tumor was composed of two cell types-filament-rich and granular cells. Granular cells contained PAS-positive, dia-stase-resistant granules that ultrastructurally corresponded to autophagic cytosegre-somes. Glial fibrillary acidic protein, the intermediate filament protein specific for astrocytes, was demonstrated in the filament-rich and, to a lesser extent, in the granular cells. Unlike noncerebral GCT, neither S-100 protein nor vimentin was detected in the tumor cells. On the other hand, both cerebral and noncerebral GCT were labeled immunocytochemically with peanut lectin (Arachis hypogaea). The results suggest that cerebral GCT share some features with noncerebral GCT, but differ in other respects. They further suggest that GCT may be derived from different cell types depending on the tissue of origin, and that cerebral GCT may be derived from astrocytes.
KW - Electron microscopy
KW - Glial fibrillary acidic protein
KW - Granular cell tumor
KW - Immunocytochemistry
KW - Lectins, peanut
KW - Myoblastoma, granular cell
KW - S-100 protein
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U2 - 10.1097/00005072-198605000-00013
DO - 10.1097/00005072-198605000-00013
M3 - Article
C2 - 3007681
AN - SCOPUS:0022479571
SN - 0022-3069
VL - 45
SP - 304
EP - 314
JO - Journal of Neuropathology and Experimental Neurology
JF - Journal of Neuropathology and Experimental Neurology
IS - 3
ER -