Cerebral granular cell tumor: Immunohistochemical and electron microscopic study

Dennis W Dickson, K. I. Suzuki, R. Kanner, S. Weitz, D. S. Horoupian

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

A rare intracerebral granular cell tumor (GCT) was studied by immunocytochemical and ultrastructural methods. The tumor was composed of two cell types-filament-rich and granular cells. Granular cells contained PAS-positive, diastase-resistant granules that ultrastructurally corresponded to autophagic cytosegresomes. Glial fibrillary acidic protein, the intermediate filament protein specific for astrocytes, was demonstrated in the filament-rich and, to a lesser extent, in the granular cells. Unlike noncerebral GCT, neither S-100 protein nor vimentin was detected in the tumor cells. On the other hand, both cerebral and noncerebral GCT were labeled immunocytochemically with peanut lectin (Arachis hypogaea). The results suggest that cerebral GCT share some features with noncerebral GCT, but differ in other respects. They further suggest that GCT may be derived from different cell types depending on the tissue of origin, and that cerebral GCT may be derived from astrocytes.

Original languageEnglish (US)
Pages (from-to)304-314
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume45
Issue number3
StatePublished - 1986
Externally publishedYes

Fingerprint

Granular Cell Tumor
Electrons
Astrocytes
Peanut Agglutinin
Intermediate Filament Proteins
S100 Proteins
Glial Fibrillary Acidic Protein
Vimentin
Amylases
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Cerebral granular cell tumor : Immunohistochemical and electron microscopic study. / Dickson, Dennis W; Suzuki, K. I.; Kanner, R.; Weitz, S.; Horoupian, D. S.

In: Journal of Neuropathology and Experimental Neurology, Vol. 45, No. 3, 1986, p. 304-314.

Research output: Contribution to journalArticle

Dickson, Dennis W ; Suzuki, K. I. ; Kanner, R. ; Weitz, S. ; Horoupian, D. S. / Cerebral granular cell tumor : Immunohistochemical and electron microscopic study. In: Journal of Neuropathology and Experimental Neurology. 1986 ; Vol. 45, No. 3. pp. 304-314.
@article{1f25854278384b3c8afa64e1be157e7d,
title = "Cerebral granular cell tumor: Immunohistochemical and electron microscopic study",
abstract = "A rare intracerebral granular cell tumor (GCT) was studied by immunocytochemical and ultrastructural methods. The tumor was composed of two cell types-filament-rich and granular cells. Granular cells contained PAS-positive, diastase-resistant granules that ultrastructurally corresponded to autophagic cytosegresomes. Glial fibrillary acidic protein, the intermediate filament protein specific for astrocytes, was demonstrated in the filament-rich and, to a lesser extent, in the granular cells. Unlike noncerebral GCT, neither S-100 protein nor vimentin was detected in the tumor cells. On the other hand, both cerebral and noncerebral GCT were labeled immunocytochemically with peanut lectin (Arachis hypogaea). The results suggest that cerebral GCT share some features with noncerebral GCT, but differ in other respects. They further suggest that GCT may be derived from different cell types depending on the tissue of origin, and that cerebral GCT may be derived from astrocytes.",
author = "Dickson, {Dennis W} and Suzuki, {K. I.} and R. Kanner and S. Weitz and Horoupian, {D. S.}",
year = "1986",
language = "English (US)",
volume = "45",
pages = "304--314",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Cerebral granular cell tumor

T2 - Immunohistochemical and electron microscopic study

AU - Dickson, Dennis W

AU - Suzuki, K. I.

AU - Kanner, R.

AU - Weitz, S.

AU - Horoupian, D. S.

PY - 1986

Y1 - 1986

N2 - A rare intracerebral granular cell tumor (GCT) was studied by immunocytochemical and ultrastructural methods. The tumor was composed of two cell types-filament-rich and granular cells. Granular cells contained PAS-positive, diastase-resistant granules that ultrastructurally corresponded to autophagic cytosegresomes. Glial fibrillary acidic protein, the intermediate filament protein specific for astrocytes, was demonstrated in the filament-rich and, to a lesser extent, in the granular cells. Unlike noncerebral GCT, neither S-100 protein nor vimentin was detected in the tumor cells. On the other hand, both cerebral and noncerebral GCT were labeled immunocytochemically with peanut lectin (Arachis hypogaea). The results suggest that cerebral GCT share some features with noncerebral GCT, but differ in other respects. They further suggest that GCT may be derived from different cell types depending on the tissue of origin, and that cerebral GCT may be derived from astrocytes.

AB - A rare intracerebral granular cell tumor (GCT) was studied by immunocytochemical and ultrastructural methods. The tumor was composed of two cell types-filament-rich and granular cells. Granular cells contained PAS-positive, diastase-resistant granules that ultrastructurally corresponded to autophagic cytosegresomes. Glial fibrillary acidic protein, the intermediate filament protein specific for astrocytes, was demonstrated in the filament-rich and, to a lesser extent, in the granular cells. Unlike noncerebral GCT, neither S-100 protein nor vimentin was detected in the tumor cells. On the other hand, both cerebral and noncerebral GCT were labeled immunocytochemically with peanut lectin (Arachis hypogaea). The results suggest that cerebral GCT share some features with noncerebral GCT, but differ in other respects. They further suggest that GCT may be derived from different cell types depending on the tissue of origin, and that cerebral GCT may be derived from astrocytes.

UR - http://www.scopus.com/inward/record.url?scp=0022479571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022479571&partnerID=8YFLogxK

M3 - Article

C2 - 3007681

AN - SCOPUS:0022479571

VL - 45

SP - 304

EP - 314

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 3

ER -