Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging

Alexandra M V Wennberg, Rodolfo Savica, Clinton E. Hagen, Rosebud O Roberts, David S Knopman, John H. Hollman, Prashanthi D Vemuri, Clifford R Jr. Jack, Ronald Carl Petersen, Michelle M Mielke

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Abstract

Objectives: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait. Design: Cross-sectional. Setting: Population-based cohort study in Olmsted County, MN. Participants: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded. Measurements: PiB-PET SUVR was measured in prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate, and motor-specific regions of interest (ROIs). Gait parameters (speed, cadence, stride length, double support time, and intra-individual stance time variability) were measured using GAITRite® instrumentation. Linear regression models were adjusted for age, sex, body mass index, education, APOE ε4 allele, Charlson comorbidity index, and depression. In secondary analyses, we additionally adjusted for neurodegeneration (hippocampal volume, FDG PET SUVR, and cortical thickness) in AD-associated regions. Results: In fully adjusted models including neuroimaging measures of neurodegeneration, higher PiB-PET SUVR across all ROIs was associated with slower gait speed (P < .05 except for the parietal ROI), lower cadence and longer double support time (P ≤ .05 except for the motor ROI), and greater stance time variability (P < .05). In sex-stratified analyses, the association between higher PiB-PET SUVR across all ROIs and measures of gait was only present among women. Conclusion: PiB-PET SUVR across ROIs, independent of general measures of AD-associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years. Longitudinal studies are needed to determine whether Aβ predicts gait decline in both women and men.

Original languageEnglish (US)
JournalJournal of the American Geriatrics Society
DOIs
StateAccepted/In press - 2016

Fingerprint

Gait
Amyloid
Gyrus Cinguli
Linear Models
Normal Pressure Hydrocephalus
Subdural Hematoma
Parietal Lobe
Neuroimaging
Alcoholism
Parkinson Disease
Longitudinal Studies
Comorbidity
Body Mass Index
Cohort Studies
Stroke
Alleles
Depression
Education
Population
Walking Speed

Keywords

  • Amyloid-beta
  • Cohort
  • Epidemiology
  • Gait
  • Neuroimaging

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{a1389c50417344b09c4c6cbf3d7be7dd,
title = "Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging",
abstract = "Objectives: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait. Design: Cross-sectional. Setting: Population-based cohort study in Olmsted County, MN. Participants: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded. Measurements: PiB-PET SUVR was measured in prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate, and motor-specific regions of interest (ROIs). Gait parameters (speed, cadence, stride length, double support time, and intra-individual stance time variability) were measured using GAITRite{\circledR} instrumentation. Linear regression models were adjusted for age, sex, body mass index, education, APOE ε4 allele, Charlson comorbidity index, and depression. In secondary analyses, we additionally adjusted for neurodegeneration (hippocampal volume, FDG PET SUVR, and cortical thickness) in AD-associated regions. Results: In fully adjusted models including neuroimaging measures of neurodegeneration, higher PiB-PET SUVR across all ROIs was associated with slower gait speed (P < .05 except for the parietal ROI), lower cadence and longer double support time (P ≤ .05 except for the motor ROI), and greater stance time variability (P < .05). In sex-stratified analyses, the association between higher PiB-PET SUVR across all ROIs and measures of gait was only present among women. Conclusion: PiB-PET SUVR across ROIs, independent of general measures of AD-associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years. Longitudinal studies are needed to determine whether Aβ predicts gait decline in both women and men.",
keywords = "Amyloid-beta, Cohort, Epidemiology, Gait, Neuroimaging",
author = "Wennberg, {Alexandra M V} and Rodolfo Savica and Hagen, {Clinton E.} and Roberts, {Rosebud O} and Knopman, {David S} and Hollman, {John H.} and Vemuri, {Prashanthi D} and Jack, {Clifford R Jr.} and Petersen, {Ronald Carl} and Mielke, {Michelle M}",
year = "2016",
doi = "10.1111/jgs.14670",
language = "English (US)",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging

AU - Wennberg, Alexandra M V

AU - Savica, Rodolfo

AU - Hagen, Clinton E.

AU - Roberts, Rosebud O

AU - Knopman, David S

AU - Hollman, John H.

AU - Vemuri, Prashanthi D

AU - Jack, Clifford R Jr.

AU - Petersen, Ronald Carl

AU - Mielke, Michelle M

PY - 2016

Y1 - 2016

N2 - Objectives: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait. Design: Cross-sectional. Setting: Population-based cohort study in Olmsted County, MN. Participants: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded. Measurements: PiB-PET SUVR was measured in prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate, and motor-specific regions of interest (ROIs). Gait parameters (speed, cadence, stride length, double support time, and intra-individual stance time variability) were measured using GAITRite® instrumentation. Linear regression models were adjusted for age, sex, body mass index, education, APOE ε4 allele, Charlson comorbidity index, and depression. In secondary analyses, we additionally adjusted for neurodegeneration (hippocampal volume, FDG PET SUVR, and cortical thickness) in AD-associated regions. Results: In fully adjusted models including neuroimaging measures of neurodegeneration, higher PiB-PET SUVR across all ROIs was associated with slower gait speed (P < .05 except for the parietal ROI), lower cadence and longer double support time (P ≤ .05 except for the motor ROI), and greater stance time variability (P < .05). In sex-stratified analyses, the association between higher PiB-PET SUVR across all ROIs and measures of gait was only present among women. Conclusion: PiB-PET SUVR across ROIs, independent of general measures of AD-associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years. Longitudinal studies are needed to determine whether Aβ predicts gait decline in both women and men.

AB - Objectives: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait. Design: Cross-sectional. Setting: Population-based cohort study in Olmsted County, MN. Participants: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded. Measurements: PiB-PET SUVR was measured in prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate, and motor-specific regions of interest (ROIs). Gait parameters (speed, cadence, stride length, double support time, and intra-individual stance time variability) were measured using GAITRite® instrumentation. Linear regression models were adjusted for age, sex, body mass index, education, APOE ε4 allele, Charlson comorbidity index, and depression. In secondary analyses, we additionally adjusted for neurodegeneration (hippocampal volume, FDG PET SUVR, and cortical thickness) in AD-associated regions. Results: In fully adjusted models including neuroimaging measures of neurodegeneration, higher PiB-PET SUVR across all ROIs was associated with slower gait speed (P < .05 except for the parietal ROI), lower cadence and longer double support time (P ≤ .05 except for the motor ROI), and greater stance time variability (P < .05). In sex-stratified analyses, the association between higher PiB-PET SUVR across all ROIs and measures of gait was only present among women. Conclusion: PiB-PET SUVR across ROIs, independent of general measures of AD-associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years. Longitudinal studies are needed to determine whether Aβ predicts gait decline in both women and men.

KW - Amyloid-beta

KW - Cohort

KW - Epidemiology

KW - Gait

KW - Neuroimaging

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