Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

Wilma L. Lingle, Ward H. Lutz, James N. Ingle, Nita J. Maihle, Jeffrey L. Salisbury

Research output: Contribution to journalArticle

405 Scopus citations

Abstract

The centrosome plays an important role in maintenance of cell polarity and in progression through the cell cycle by determining the number, polarity, and organization of interphase and mitotic microtubules. By examining a set of 35 high grade human breast tumors, we show that centrosomes of adenocarcinoma cells generally display abnormal structure, aberrant protein phosphorylation, and increased microtubule nucleating capacity in comparison to centrosomes of normal breast epithelial and stromal tissues. These structural and functional centrosome defects have important implications for understanding the mechanisms by which genomic instability and loss of cell polarity develop in solid tumors.

Original languageEnglish (US)
Pages (from-to)2950-2955
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number6
DOIs
StatePublished - Mar 17 1998

ASJC Scopus subject areas

  • General

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