Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity

Feng Gao, Bette T. Korber, Eric A. Weaver, Hua Xin Liao, Beatrice H. Hahn, Barton F. Haynes

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Genetic variation of HIV-1 represents a major obstacle for AIDS vaccine development. With the amino acid sequence divergence as high as 30% in envelopes between different subtypes among HIV-1 group M viruses, it is unlikely that cross-subtype protection will occur equally well among all subtypes. Computer programs have been used to generate 'centralized' HIV gene sequences: consensus, ancestor or center of the free. These sequences can decrease the genetic distances between the 'centralized' and wild-type gene immunogens to half of those between any wild-type immuongens to each other, Recent studies demonstrated that an artificial group M consensus env gene is equidistant from any subtype and recombinants. It is biologically functional and preserves antigenicity similar to contemporary Env proteins. Most importantly, the group M consensus Env immunogen can elicit both T- and B-cell responses to wild-type HIV-1 isolates.

Original languageEnglish (US)
JournalExpert Review of Vaccines
Volume3
Issue number4 SUPPL.
DOIs
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

HIV-1
Vaccines
Cross Protection
env Gene Products
env Genes
AIDS Vaccines
Consensus Sequence
Genes
Amino Acid Sequence
B-Lymphocytes
Software
HIV
Viruses

Keywords

  • Consensus
  • Diversity
  • Immunogen
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Gao, F., Korber, B. T., Weaver, E. A., Liao, H. X., Hahn, B. H., & Haynes, B. F. (2004). Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. Expert Review of Vaccines, 3(4 SUPPL.). https://doi.org/10.1586/14760584.3.4.S161

Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. / Gao, Feng; Korber, Bette T.; Weaver, Eric A.; Liao, Hua Xin; Hahn, Beatrice H.; Haynes, Barton F.

In: Expert Review of Vaccines, Vol. 3, No. 4 SUPPL., 08.2004.

Research output: Contribution to journalArticle

Gao, F, Korber, BT, Weaver, EA, Liao, HX, Hahn, BH & Haynes, BF 2004, 'Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity', Expert Review of Vaccines, vol. 3, no. 4 SUPPL.. https://doi.org/10.1586/14760584.3.4.S161
Gao, Feng ; Korber, Bette T. ; Weaver, Eric A. ; Liao, Hua Xin ; Hahn, Beatrice H. ; Haynes, Barton F. / Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. In: Expert Review of Vaccines. 2004 ; Vol. 3, No. 4 SUPPL.
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