Cellular therapies for type 1 diabetes

D. D. Lee, E. Grossman, A. S. Chong

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Type 1 diabetes mellitus (T1DM) is a disease that results from the selective autoimmune destruction of insulin-producing β-cells. This disease process lends itself to cellular therapy because of the single cell nature of insulin production. Murine models have provided opportunities for the study of cellular therapies for the treatment of diabetes, including the investigation of islet transplantation, and also the possibility of stem cell therapies and islet regeneration. Studies in islet transplantation have included both allo-and xeno-transplantation and have allowed for the study of new approaches for the reversal of autoimmunity and achieving immune tolerance. Stem cells from hematopoietic sources such as bone marrow and fetal cord blood, as well as from the pancreas, intestine, liver, and spleen promise either new sources of islets or may function as stimulators of islet regeneration. This review will summarize the various cellular interventions investigated as potential treatments of T1DM.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalHormone and Metabolic Research
Volume40
Issue number2
DOIs
StatePublished - Feb 1 2008

Keywords

  • Islet transplantation
  • Stem cell therapy
  • Type 1 diabetes mellitus
  • β-cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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