Cellular Senescence in Aging Lungs and Diseases

Arbi Aghali, Maunick Lefin Koloko Ngassie, Christina M. Pabelick, Y. S. Prakash

Research output: Contribution to journalReview articlepeer-review

Abstract

Cellular senescence represents a state of irreversible cell cycle arrest occurring naturally or in response to exogenous stressors. Following the initial arrest, progressive phenotypic changes define conditions of cellular senescence. Understanding molecular mechanisms that drive senescence can help to recognize the importance of such pathways in lung health and disease. There is increasing interest in the role of cellular senescence in conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) in the context of understanding pathophysiology and identification of novel therapies. Herein, we discuss the current knowledge of molecular mechanisms and mitochondrial dysfunction regulating different aspects of cellular se-nescence-related to chronic lung diseases to develop rational strategies for modulating the senescent cell phenotype in the lung for therapeutic benefit.

Original languageEnglish (US)
Article number1781
JournalCells
Volume11
Issue number11
DOIs
StatePublished - Jun 1 2022

Keywords

  • aging
  • asthma
  • COPD
  • lung diseases
  • mitochondrial dysfunction
  • pulmonary fibrosis
  • remodeling
  • senescence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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