Cellular senescence and DNA repair

Zhenkun Lou, Junjie Chen

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Aging is a complex process that results in functional decline and mortality of the organisms. On the cellular lever, cellular senescence has been used as a model for aging. Therefore, understanding cellular senescence has important health implications. Initial observations suggest that cellular senescence is the result of telomere shortening. Recent findings suggest that cellular senescence could be triggered by DNA damage. In fact, both telomere shortening and DNA-damage-induced cellular senescence share a common mechanism, the DNA damage response pathway. This review will discuss the link between DNA repair defects and cellular senescence.

Original languageEnglish (US)
Pages (from-to)2641-2646
Number of pages6
JournalExperimental Cell Research
Volume312
Issue number14
DOIs
StatePublished - Aug 15 2006

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ASJC Scopus subject areas

  • Cell Biology

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