TY - JOUR
T1 - Cellular senescence and DNA repair
AU - Lou, Zhenkun
AU - Chen, Junjie
PY - 2006/8/15
Y1 - 2006/8/15
N2 - Aging is a complex process that results in functional decline and mortality of the organisms. On the cellular lever, cellular senescence has been used as a model for aging. Therefore, understanding cellular senescence has important health implications. Initial observations suggest that cellular senescence is the result of telomere shortening. Recent findings suggest that cellular senescence could be triggered by DNA damage. In fact, both telomere shortening and DNA-damage-induced cellular senescence share a common mechanism, the DNA damage response pathway. This review will discuss the link between DNA repair defects and cellular senescence.
AB - Aging is a complex process that results in functional decline and mortality of the organisms. On the cellular lever, cellular senescence has been used as a model for aging. Therefore, understanding cellular senescence has important health implications. Initial observations suggest that cellular senescence is the result of telomere shortening. Recent findings suggest that cellular senescence could be triggered by DNA damage. In fact, both telomere shortening and DNA-damage-induced cellular senescence share a common mechanism, the DNA damage response pathway. This review will discuss the link between DNA repair defects and cellular senescence.
UR - http://www.scopus.com/inward/record.url?scp=33746691847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746691847&partnerID=8YFLogxK
U2 - 10.1016/j.yexcr.2006.06.009
DO - 10.1016/j.yexcr.2006.06.009
M3 - Review article
C2 - 16893723
AN - SCOPUS:33746691847
SN - 0014-4827
VL - 312
SP - 2641
EP - 2646
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 14
ER -