Cells as vehicles for cancer gene therapy: The missing link between targeted vectors and systemic delivery?

Kevin Harrington, Luis Alvarez-Vallina, Marka Crittenden, Michael Gough, Heung Chong, Rosa Maria Diaz, Georges Vassaux, Nicholas Lemoine, Richard Vile

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Systemic administration of currently manufactured viral stocks has not so far achieved sufficient circulating titers to allow therapeutic targeting of metastatic disease. This is due to low initial viral titers, immune inactivation, nonspecific adhesion, and loss of particles. One way to exploit the elegant molecular manipulations that have been made to increase vector targeting is to protect these vectors until they reach the local sites of tumor growth. Various cell types home preferentially to tumors and can be loaded with the constructs required to produce targeted vectors. Here we discuss the potential of using such cell carriers to chaperone precious vectors directly to the tumors. The vectors can incorporate mechanisms to achieve tumor site-inducible expression, along with tumor cell-specific expression of the therapeutic gene and/or replicating viral genomes that would be released at the tumor. In this way, the great advances that have so far been made with the engineering of vector tropisms might be genuinely exploited and converted into clinical benefit.

Original languageEnglish (US)
Pages (from-to)1263-1280
Number of pages18
JournalHuman gene therapy
Volume13
Issue number11
DOIs
StatePublished - Jul 20 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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