Celiac disease

Advances in diagnosis

Melissa R. Snyder, Joseph A Murray

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Celiac disease (CD) is characterized by small intestinal damage, which is mediated by a gluten-driven inflammatory response. Establishing a robust diagnosis is critical for improved quality of life and prevention of co-morbidities, although treatment is associated with a substantial life-long burden of care for patients and families. Unfortunately, CD remains a challenging diagnosis. As awareness of the disease increases, more diagnoses of CD are being made by primary care physicians. In fact, many patients may not present to a gastroenterologist because their symptoms are not clearly linked to a gastrointestinal pathology. Also, many patients are starting a gluten-free diet without prior testing, a circumstance that leads to even more confusion. Lastly, the number of serologic and genetic tests, and the role of endoscopy, can be confusing. The purpose of this review is to examine diagnostic testing strategies, focusing on published guidelines, for the evaluation of patients with suspected CD.

Original languageEnglish (US)
Pages (from-to)449-463
Number of pages15
JournalExpert Review of Clinical Immunology
Volume12
Issue number4
DOIs
StatePublished - Apr 2 2016

Fingerprint

Celiac Disease
Gluten-Free Diet
Confusion
Glutens
Primary Care Physicians
Serologic Tests
Endoscopy
Patient Care
Quality of Life
Guidelines
Pathology
Morbidity
Therapeutics

Keywords

  • Celiac disease
  • deamidated gliadin
  • gluten sensitivity
  • HLADQ2/DQ8
  • small intestinal biopsy
  • tissue transglutaminase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Celiac disease : Advances in diagnosis. / Snyder, Melissa R.; Murray, Joseph A.

In: Expert Review of Clinical Immunology, Vol. 12, No. 4, 02.04.2016, p. 449-463.

Research output: Contribution to journalReview article

Snyder, Melissa R. ; Murray, Joseph A. / Celiac disease : Advances in diagnosis. In: Expert Review of Clinical Immunology. 2016 ; Vol. 12, No. 4. pp. 449-463.
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