Cats are protected against feline immunodeficiency virus infection following vaccination with a homologous AP-1 binding site-deleted mutant

M. Kohmoto, T. Miyazawa, E. Sato, K. Uetsuka, Y. Nishimura, Y. Ikeda, G. Inada, K. Doi, T. Mikami

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Following establishment, via the vaginal route, of infection with an AP-1 binding-site deleted mutant (ΔAP-1) of feline immunodeficiency virus (FIV), cats were challenged with a homologous intact strain (TM2) of FIV. The cats were observed for 23 weeks to evaluate the efficacy of the ΔAP-1 against the homologous TM2 strain challenge. These two viruses were differentiated by Southern blotting after amplification of proviral DNA by semi-nested polymerase chain reaction in DNAs of peripheral blood mononuclear cells and tissues. A TM2-specific band was detected in one cat exposed to but not infected with ΔAP-1, but not in two ΔAP-1-infected. These results indicate that ΔAP-1 could protect against subsequent challenge with homologous FIV TM2 strain.

Original languageEnglish (US)
Pages (from-to)1839-1845
Number of pages7
JournalArchives of Virology
Volume143
Issue number9
DOIs
StatePublished - Oct 12 1998

ASJC Scopus subject areas

  • Virology

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