@article{47795a260e504388b47b32c6bd7b9344,
title = "Case report: Toxic delirium in a patient taking amantadine and trimethoprim-sulfamethoxazole",
abstract = "Acute mental confusion occurred in a patient on a stable dose of amantadine after he was started on trimethoprim-sulfamethoxazole. Discontinuation of the drugs led to rapid improvement. Studies in a rat model of organic cation secretion demonstrate that both amantadine and trimethoprim, but not sulfamethoxazole, inhibit the renal secretion of the organic cation procainamide. This case may represent an amantadine-trimethoprim interaction.",
keywords = "amantadine, drug interaction, renal secretion, trimethoprim",
author = "Speeg, {K. V.} and Leighton, {J. A.} and Maldonado, {A. L.}",
note = "Funding Information: From the Division of Gastroenterology, Department of Medicine, The University of Texas Health Science Center, and A. L. Murphy VA Hospital, San Antonio, Texas. This study was supported in part by the Medical Research Service of the Veterans Administration. The authors gratefully acknowledge the excellent medical care provided to the patient by Drs. Sue Crow and Mark Rodriguez. Correspondence: Dr. K. V. Speeg, Department of Medicine, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78284.",
year = "1989",
doi = "10.1097/00000441-198912000-00010",
language = "English (US)",
volume = "298",
pages = "410--412",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "6",
}