Case of granulocyte colony-stimulating factor-induced Sweet's syndrome

Kenneth R. Arbetter, Kelly W. Hubbard, Svetomir Nenad Markovic, Lawrence E. Gibson, Robert L. Phyliky

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A 33-year-old male was referred with a two-week history of fevers to 40°C and painful, erythematous skin and oral mucosal eruptions that had failed to respond to multiple anti-infectious agents. He had a recent diagnosis of a 'myeloproliferative disorder with myelodysplastic features' on bone marrow biopsy, with associated pancytopenia. Two weeks before admission, he had been treated with a course of granulocyte colony-stimulating factor (G-CSF) at a dose of 300 μg/day in an attempt to improve his neutropenia. After four days of treatment, the fever and lesions developed. Infectious evaluation was negative; however, biopsies of the skin and oral mucosal lesions revealed histology consistent with Sweet's syndrome. Intravenous methylprednisolone (30 mg/day) was started with prompt defervescence and resolution of the lesions within days. With the increasing use of G-CSF, Sweet's syndrome is becoming more commonly recognized as an adverse effect. This is the first case of G-CSF-induced Sweet's syndrome to demonstrate gingival involvement.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalAmerican Journal of Hematology
Volume61
Issue number2
DOIs
StatePublished - 1999

Fingerprint

Sweet Syndrome
Granulocyte Colony-Stimulating Factor
Fever
Biopsy
Myeloproliferative Disorders
Skin
Pancytopenia
Methylprednisolone
Neutropenia
Histology
Bone Marrow
Therapeutics

Keywords

  • G-CSF
  • Leukopenia
  • Sweet's syndrome

ASJC Scopus subject areas

  • Hematology

Cite this

Case of granulocyte colony-stimulating factor-induced Sweet's syndrome. / Arbetter, Kenneth R.; Hubbard, Kelly W.; Markovic, Svetomir Nenad; Gibson, Lawrence E.; Phyliky, Robert L.

In: American Journal of Hematology, Vol. 61, No. 2, 1999, p. 126-129.

Research output: Contribution to journalArticle

Arbetter, Kenneth R. ; Hubbard, Kelly W. ; Markovic, Svetomir Nenad ; Gibson, Lawrence E. ; Phyliky, Robert L. / Case of granulocyte colony-stimulating factor-induced Sweet's syndrome. In: American Journal of Hematology. 1999 ; Vol. 61, No. 2. pp. 126-129.
@article{440652a25ee943e5b128e2fcef7541c8,
title = "Case of granulocyte colony-stimulating factor-induced Sweet's syndrome",
abstract = "A 33-year-old male was referred with a two-week history of fevers to 40°C and painful, erythematous skin and oral mucosal eruptions that had failed to respond to multiple anti-infectious agents. He had a recent diagnosis of a 'myeloproliferative disorder with myelodysplastic features' on bone marrow biopsy, with associated pancytopenia. Two weeks before admission, he had been treated with a course of granulocyte colony-stimulating factor (G-CSF) at a dose of 300 μg/day in an attempt to improve his neutropenia. After four days of treatment, the fever and lesions developed. Infectious evaluation was negative; however, biopsies of the skin and oral mucosal lesions revealed histology consistent with Sweet's syndrome. Intravenous methylprednisolone (30 mg/day) was started with prompt defervescence and resolution of the lesions within days. With the increasing use of G-CSF, Sweet's syndrome is becoming more commonly recognized as an adverse effect. This is the first case of G-CSF-induced Sweet's syndrome to demonstrate gingival involvement.",
keywords = "G-CSF, Leukopenia, Sweet's syndrome",
author = "Arbetter, {Kenneth R.} and Hubbard, {Kelly W.} and Markovic, {Svetomir Nenad} and Gibson, {Lawrence E.} and Phyliky, {Robert L.}",
year = "1999",
doi = "10.1002/(SICI)1096-8652(199906)61:2<126::AID-AJH9>3.0.CO;2-8",
language = "English (US)",
volume = "61",
pages = "126--129",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Case of granulocyte colony-stimulating factor-induced Sweet's syndrome

AU - Arbetter, Kenneth R.

AU - Hubbard, Kelly W.

AU - Markovic, Svetomir Nenad

AU - Gibson, Lawrence E.

AU - Phyliky, Robert L.

PY - 1999

Y1 - 1999

N2 - A 33-year-old male was referred with a two-week history of fevers to 40°C and painful, erythematous skin and oral mucosal eruptions that had failed to respond to multiple anti-infectious agents. He had a recent diagnosis of a 'myeloproliferative disorder with myelodysplastic features' on bone marrow biopsy, with associated pancytopenia. Two weeks before admission, he had been treated with a course of granulocyte colony-stimulating factor (G-CSF) at a dose of 300 μg/day in an attempt to improve his neutropenia. After four days of treatment, the fever and lesions developed. Infectious evaluation was negative; however, biopsies of the skin and oral mucosal lesions revealed histology consistent with Sweet's syndrome. Intravenous methylprednisolone (30 mg/day) was started with prompt defervescence and resolution of the lesions within days. With the increasing use of G-CSF, Sweet's syndrome is becoming more commonly recognized as an adverse effect. This is the first case of G-CSF-induced Sweet's syndrome to demonstrate gingival involvement.

AB - A 33-year-old male was referred with a two-week history of fevers to 40°C and painful, erythematous skin and oral mucosal eruptions that had failed to respond to multiple anti-infectious agents. He had a recent diagnosis of a 'myeloproliferative disorder with myelodysplastic features' on bone marrow biopsy, with associated pancytopenia. Two weeks before admission, he had been treated with a course of granulocyte colony-stimulating factor (G-CSF) at a dose of 300 μg/day in an attempt to improve his neutropenia. After four days of treatment, the fever and lesions developed. Infectious evaluation was negative; however, biopsies of the skin and oral mucosal lesions revealed histology consistent with Sweet's syndrome. Intravenous methylprednisolone (30 mg/day) was started with prompt defervescence and resolution of the lesions within days. With the increasing use of G-CSF, Sweet's syndrome is becoming more commonly recognized as an adverse effect. This is the first case of G-CSF-induced Sweet's syndrome to demonstrate gingival involvement.

KW - G-CSF

KW - Leukopenia

KW - Sweet's syndrome

UR - http://www.scopus.com/inward/record.url?scp=0032977705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032977705&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-8652(199906)61:2<126::AID-AJH9>3.0.CO;2-8

DO - 10.1002/(SICI)1096-8652(199906)61:2<126::AID-AJH9>3.0.CO;2-8

M3 - Article

C2 - 10367792

AN - SCOPUS:0032977705

VL - 61

SP - 126

EP - 129

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 2

ER -