Case-control study of the α-synuclein interacting protein gene and Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, Timothy G. Lesnick, Mariza de Andrade, James H. Bower, Dena Hernandez, John A. Hardy, Walter A. Rocca

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We conducted a case-control study of the α-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5′ terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the α-synuclein gene (SNCA) or the parkin (PARK2) gene.

Original languageEnglish (US)
Pages (from-to)1233-1239
Number of pages7
JournalMovement Disorders
Volume18
Issue number11
DOIs
StatePublished - Nov 2003

Keywords

  • Alpha-synuclein
  • Association
  • Interactions
  • Parkin
  • Parkinson's disease
  • Susceptibility genes
  • Synphilin-1

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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