Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease

John L. Goudreau; Demetrius M. Maraganore; Matthew J. Farrer; Timothy G. Lesnick; Andrew B. Singleton; James H. Bower; John A. Hardy; Walter A. Rocca

doi:10.1002/mds.10268

Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease

John L. Goudreau, Demetrius M. Maraganore, Matthew J. Farrer, Timothy G. Lesnick, Andrew B. Singleton, James H. Bower, John A. Hardy, Walter A. Rocca

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

We investigated the association of Parkinson's disease (PD) with dopamine transporter-1 (DAT1), monoamine oxidase-B (MAO-B), and catechol-O-methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1-3′-variable numbers of tandem repeats, the MAO-B-(GT)_n, and the COMT-Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO-B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings.

Original language	English (US)
Pages (from-to)	1305-1311
Number of pages	7
Journal	Movement Disorders
Volume	17
Issue number	6
DOIs	https://doi.org/10.1002/mds.10268
State	Published - Nov 2002

Keywords

COMT
Case-control study
DAT1
MAO-B
Parkinson's disease
Polymorphisms
Susceptibility genes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.10268

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title = "Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease",

abstract = "We investigated the association of Parkinson's disease (PD) with dopamine transporter-1 (DAT1), monoamine oxidase-B (MAO-B), and catechol-O-methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1-3′-variable numbers of tandem repeats, the MAO-B-(GT)n, and the COMT-Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO-B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings.",

keywords = "COMT, Case-control study, DAT1, MAO-B, Parkinson's disease, Polymorphisms, Susceptibility genes",

author = "Goudreau, {John L.} and Maraganore, {Demetrius M.} and Farrer, {Matthew J.} and Lesnick, {Timothy G.} and Singleton, {Andrew B.} and Bower, {James H.} and Hardy, {John A.} and Rocca, {Walter A.}",

year = "2002",

month = nov,

doi = "10.1002/mds.10268",

language = "English (US)",

volume = "17",

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journal = "Movement Disorders",

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AU - Goudreau, John L.

AU - Maraganore, Demetrius M.

AU - Farrer, Matthew J.

AU - Lesnick, Timothy G.

AU - Singleton, Andrew B.

AU - Bower, James H.

AU - Hardy, John A.

AU - Rocca, Walter A.

PY - 2002/11

Y1 - 2002/11

N2 - We investigated the association of Parkinson's disease (PD) with dopamine transporter-1 (DAT1), monoamine oxidase-B (MAO-B), and catechol-O-methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1-3′-variable numbers of tandem repeats, the MAO-B-(GT)n, and the COMT-Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO-B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings.

AB - We investigated the association of Parkinson's disease (PD) with dopamine transporter-1 (DAT1), monoamine oxidase-B (MAO-B), and catechol-O-methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1-3′-variable numbers of tandem repeats, the MAO-B-(GT)n, and the COMT-Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO-B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings.

KW - COMT

KW - Case-control study

KW - DAT1

KW - MAO-B

KW - Parkinson's disease

KW - Polymorphisms

KW - Susceptibility genes

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Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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