Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease

John L. Goudreau, Demetrius M. Maraganore, Matthew J. Farrer, Timothy G. Lesnick, Andrew B. Singleton, James H. Bower, John A. Hardy, Walter A. Rocca

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We investigated the association of Parkinson's disease (PD) with dopamine transporter-1 (DAT1), monoamine oxidase-B (MAO-B), and catechol-O-methyltransferase (COMT) gene polymorphisms. Overall, we observed no significant association of PD with the DAT1-3′-variable numbers of tandem repeats, the MAO-B-(GT)n, and the COMT-Val108Met gene polymorphisms in a sample of 319 unrelated PD cases and 196 control subjects. Analyses stratified by sex, age at examination, family history of PD, and ethnic origin also yielded negative findings, with three exceptions. We found statistically significant associations of PD with MAO-B polymorphisms in older patients and with a COMT polymorphism in younger subjects and in women. These significant differences at the two-tailed alpha level of 0.05 and restricted to subgroup analyses may have a biological basis or may be chance findings.

Original languageEnglish (US)
Pages (from-to)1305-1311
Number of pages7
JournalMovement Disorders
Volume17
Issue number6
DOIs
StatePublished - Nov 2002

Keywords

  • COMT
  • Case-control study
  • DAT1
  • MAO-B
  • Parkinson's disease
  • Polymorphisms
  • Susceptibility genes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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