Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid

Bela Melegh, Maria Pap, Eva Morava-Kozicz, Denes Molnar, Maria Dani, Judit Kurucz

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Energy metabolism was measured in children receiving long-term treatment with valproic acid. In 8 of 10 randomly selected subjects, the resting respiratory quotient was higher than in age- and sex-matched control subjects (0.91 ± 0.01 vs 0.87 ± 0.01; p <0.05). A shift was observed in fuel consumption, and a significant reduction was found in the amount of fats oxidized (0.68 ± 0.23 vs 1.18 ± 0.18 gm · kg-1 · day-1), which was accompanied by increased utilization of carbohydrates (5.31 ± 0.79 vs 3.81 ± 0.39 gm · kg-1 · day-1) in comparison with the control subjects. The resting total energy expenditure was not affected by the treatment. The children with an altered energy consumption pattern (n = 8) received carnitine supplementation for a month; the respiratory quotient then decreased (0.87 ± 0.02), the oxidation of fats increased (1.42 ± 0.25), and the consumption of carbohydrates decreased (3.87 ± 0.79), but no changes in resting energy expenditure were observed. We conclude that carnitine depletion, a known adverse effect of valproic acid administration, may result in inhibited fatty acid oxidation, leading to a shift of substrates utilized from fats to carbohydrates. (J PEDIATR 1994;125:317-21).

Original languageEnglish (US)
Pages (from-to)317-321
Number of pages5
JournalThe Journal of Pediatrics
Volume125
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Carnitine
Valproic Acid
Energy Metabolism
Fats
Carbohydrates
Fatty Acids
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid. / Melegh, Bela; Pap, Maria; Morava-Kozicz, Eva; Molnar, Denes; Dani, Maria; Kurucz, Judit.

In: The Journal of Pediatrics, Vol. 125, No. 2, 01.01.1994, p. 317-321.

Research output: Contribution to journalArticle

Melegh, Bela ; Pap, Maria ; Morava-Kozicz, Eva ; Molnar, Denes ; Dani, Maria ; Kurucz, Judit. / Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid. In: The Journal of Pediatrics. 1994 ; Vol. 125, No. 2. pp. 317-321.
@article{8c3e8ca4ad0640448eb65b27a25bab64,
title = "Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid",
abstract = "Energy metabolism was measured in children receiving long-term treatment with valproic acid. In 8 of 10 randomly selected subjects, the resting respiratory quotient was higher than in age- and sex-matched control subjects (0.91 ± 0.01 vs 0.87 ± 0.01; p <0.05). A shift was observed in fuel consumption, and a significant reduction was found in the amount of fats oxidized (0.68 ± 0.23 vs 1.18 ± 0.18 gm · kg-1 · day-1), which was accompanied by increased utilization of carbohydrates (5.31 ± 0.79 vs 3.81 ± 0.39 gm · kg-1 · day-1) in comparison with the control subjects. The resting total energy expenditure was not affected by the treatment. The children with an altered energy consumption pattern (n = 8) received carnitine supplementation for a month; the respiratory quotient then decreased (0.87 ± 0.02), the oxidation of fats increased (1.42 ± 0.25), and the consumption of carbohydrates decreased (3.87 ± 0.79), but no changes in resting energy expenditure were observed. We conclude that carnitine depletion, a known adverse effect of valproic acid administration, may result in inhibited fatty acid oxidation, leading to a shift of substrates utilized from fats to carbohydrates. (J PEDIATR 1994;125:317-21).",
author = "Bela Melegh and Maria Pap and Eva Morava-Kozicz and Denes Molnar and Maria Dani and Judit Kurucz",
year = "1994",
month = "1",
day = "1",
doi = "10.1016/S0022-3476(94)70218-7",
language = "English (US)",
volume = "125",
pages = "317--321",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Carnitine-dependent changes of metabolic fuel consumption during long-term treatment with valproic acid

AU - Melegh, Bela

AU - Pap, Maria

AU - Morava-Kozicz, Eva

AU - Molnar, Denes

AU - Dani, Maria

AU - Kurucz, Judit

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Energy metabolism was measured in children receiving long-term treatment with valproic acid. In 8 of 10 randomly selected subjects, the resting respiratory quotient was higher than in age- and sex-matched control subjects (0.91 ± 0.01 vs 0.87 ± 0.01; p <0.05). A shift was observed in fuel consumption, and a significant reduction was found in the amount of fats oxidized (0.68 ± 0.23 vs 1.18 ± 0.18 gm · kg-1 · day-1), which was accompanied by increased utilization of carbohydrates (5.31 ± 0.79 vs 3.81 ± 0.39 gm · kg-1 · day-1) in comparison with the control subjects. The resting total energy expenditure was not affected by the treatment. The children with an altered energy consumption pattern (n = 8) received carnitine supplementation for a month; the respiratory quotient then decreased (0.87 ± 0.02), the oxidation of fats increased (1.42 ± 0.25), and the consumption of carbohydrates decreased (3.87 ± 0.79), but no changes in resting energy expenditure were observed. We conclude that carnitine depletion, a known adverse effect of valproic acid administration, may result in inhibited fatty acid oxidation, leading to a shift of substrates utilized from fats to carbohydrates. (J PEDIATR 1994;125:317-21).

AB - Energy metabolism was measured in children receiving long-term treatment with valproic acid. In 8 of 10 randomly selected subjects, the resting respiratory quotient was higher than in age- and sex-matched control subjects (0.91 ± 0.01 vs 0.87 ± 0.01; p <0.05). A shift was observed in fuel consumption, and a significant reduction was found in the amount of fats oxidized (0.68 ± 0.23 vs 1.18 ± 0.18 gm · kg-1 · day-1), which was accompanied by increased utilization of carbohydrates (5.31 ± 0.79 vs 3.81 ± 0.39 gm · kg-1 · day-1) in comparison with the control subjects. The resting total energy expenditure was not affected by the treatment. The children with an altered energy consumption pattern (n = 8) received carnitine supplementation for a month; the respiratory quotient then decreased (0.87 ± 0.02), the oxidation of fats increased (1.42 ± 0.25), and the consumption of carbohydrates decreased (3.87 ± 0.79), but no changes in resting energy expenditure were observed. We conclude that carnitine depletion, a known adverse effect of valproic acid administration, may result in inhibited fatty acid oxidation, leading to a shift of substrates utilized from fats to carbohydrates. (J PEDIATR 1994;125:317-21).

UR - http://www.scopus.com/inward/record.url?scp=0028059055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028059055&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(94)70218-7

DO - 10.1016/S0022-3476(94)70218-7

M3 - Article

C2 - 8040784

AN - SCOPUS:0028059055

VL - 125

SP - 317

EP - 321

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 2

ER -