Cardiovascular side effects of atomoxetine and its interactions with inhibitors of the cytochrome p450 system

Pashtoon Murtaza Kasi, Rawad Mounzer, George H. Gleeson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor (SNRI), one of the first medications in the nonstimulant class of medications that has been approved by the FDA for the treatment of ADHD. Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. Cardiovascular side effects are less commonly reported. The increase in the noradrenergic tone may explain some of the side effects noted with the use of this medication. Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug.

Original languageEnglish (US)
Article number952584
JournalCase Reports in Medicine
Volume2011
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Cytochrome P-450 Enzyme System
Attention Deficit Disorder with Hyperactivity
Orthostatic Hypotension
Fluoxetine
Syncope
Tachycardia
Antidepressive Agents
Norepinephrine
Pharmacokinetics
Atomoxetine Hydrochloride
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cardiovascular side effects of atomoxetine and its interactions with inhibitors of the cytochrome p450 system. / Kasi, Pashtoon Murtaza; Mounzer, Rawad; Gleeson, George H.

In: Case Reports in Medicine, Vol. 2011, 952584, 2011.

Research output: Contribution to journalArticle

@article{380efe70c646468b9fac8fcdb2234035,
title = "Cardiovascular side effects of atomoxetine and its interactions with inhibitors of the cytochrome p450 system",
abstract = "Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor (SNRI), one of the first medications in the nonstimulant class of medications that has been approved by the FDA for the treatment of ADHD. Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. Cardiovascular side effects are less commonly reported. The increase in the noradrenergic tone may explain some of the side effects noted with the use of this medication. Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug.",
author = "Kasi, {Pashtoon Murtaza} and Rawad Mounzer and Gleeson, {George H.}",
year = "2011",
doi = "10.1155/2011/952584",
language = "English (US)",
volume = "2011",
journal = "Case Reports in Medicine",
issn = "1687-9627",
publisher = "Hindawi Limited",

}

TY - JOUR

T1 - Cardiovascular side effects of atomoxetine and its interactions with inhibitors of the cytochrome p450 system

AU - Kasi, Pashtoon Murtaza

AU - Mounzer, Rawad

AU - Gleeson, George H.

PY - 2011

Y1 - 2011

N2 - Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor (SNRI), one of the first medications in the nonstimulant class of medications that has been approved by the FDA for the treatment of ADHD. Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. Cardiovascular side effects are less commonly reported. The increase in the noradrenergic tone may explain some of the side effects noted with the use of this medication. Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug.

AB - Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor (SNRI), one of the first medications in the nonstimulant class of medications that has been approved by the FDA for the treatment of ADHD. Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. Cardiovascular side effects are less commonly reported. The increase in the noradrenergic tone may explain some of the side effects noted with the use of this medication. Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug.

UR - http://www.scopus.com/inward/record.url?scp=84868005176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868005176&partnerID=8YFLogxK

U2 - 10.1155/2011/952584

DO - 10.1155/2011/952584

M3 - Article

AN - SCOPUS:84868005176

VL - 2011

JO - Case Reports in Medicine

JF - Case Reports in Medicine

SN - 1687-9627

M1 - 952584

ER -