TY - JOUR
T1 - Cardiovascular pharmacogenomics and individualized drug therapy
AU - Pereira, Naveen L.
AU - Weinshilboum, Richard M.
N1 - Funding Information:
Supported in part by HL 84904 (Heart Failure Clinical Research Network), a Marie Ingalls Cardiovascular Career Development Award (N. L. Pereira), a PhRMA Foundation “Center of Excellence in Clinical Pharmacology” Award (R. M. Weinshilboum), and NIH grants UL1RR24150 (N. L. Pereira), R01 GM28157 (R. M. Weinshilboum), R01 CA132780 (R. M. Weinshilboum) and U01 GM61388 (The Pharmacogenetics Research Network). We thank L. Wussow for her assistance with the preparation of this manuscript.
PY - 2009/10
Y1 - 2009/10
N2 - The goal of individualized drug therapy requires physicians to be able to accurately predict an individual’s response to a drug. Both genetic and environmental factors are known to influence drugresponse. ‘Pharmacogenetics’ is the study of the role of inheritance in variation in drug response phenotypes.Pharmacogenetics is now moving genome-wide to become ‘pharmacogenomics’, resulting in the recognition ofnovel biomarkers for individual variation in drug response. This article reviews the development, promise andchallenges facing pharmacogenomics, using examples of drugs used to treat or prevent cardiovascular disease.
AB - The goal of individualized drug therapy requires physicians to be able to accurately predict an individual’s response to a drug. Both genetic and environmental factors are known to influence drugresponse. ‘Pharmacogenetics’ is the study of the role of inheritance in variation in drug response phenotypes.Pharmacogenetics is now moving genome-wide to become ‘pharmacogenomics’, resulting in the recognition ofnovel biomarkers for individual variation in drug response. This article reviews the development, promise andchallenges facing pharmacogenomics, using examples of drugs used to treat or prevent cardiovascular disease.
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U2 - 10.1038/nrcardio.2009.154
DO - 10.1038/nrcardio.2009.154
M3 - Article
C2 - 19707183
AN - SCOPUS:79958085599
SN - 1759-5002
VL - 6
SP - 632
EP - 638
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 10
ER -