Cardiovascular pharmacogenomics and individualized drug therapy

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

The goal of individualized drug therapy requires physicians to be able to accurately predict an individual’s response to a drug. Both genetic and environmental factors are known to influence drugresponse. ‘Pharmacogenetics’ is the study of the role of inheritance in variation in drug response phenotypes.Pharmacogenetics is now moving genome-wide to become ‘pharmacogenomics’, resulting in the recognition ofnovel biomarkers for individual variation in drug response. This article reviews the development, promise andchallenges facing pharmacogenomics, using examples of drugs used to treat or prevent cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)632-638
Number of pages7
JournalNature Reviews Cardiology
Volume6
Issue number10
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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