Abstract
The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis. PCR was used to establish the diagnosis in four cases. In two instances, paired single lung transplant recipients manifested infection, and in one of these pairs, isolates were indistinguishable by multilocus sequence typing (MLST). To investigate the prevalence of M. hominis in the lower respiratory tract, we tested 178 bronchoalveolar lavage (BAL) fluids collected from immunocompromised subjects for M. hominis by PCR; all were negative. Review of the literature revealed an additional 15 cases of M. hominis in lung transplant recipients, most with similar clinical presentations to our cases. We recommend that M. hominis should be considered in post-cardiothoracic transplant infections presenting with pleuritis, surgical site infection, or mediastinitis. M. hominis PCR may facilitate early diagnosis and prompt therapy. Evaluation for possible donor transmission should be considered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-90 |
| Number of pages | 7 |
| Journal | EBioMedicine |
| Volume | 19 |
| DOIs | |
| State | Published - May 1 2017 |
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Keywords
- Cardiothoracic transplantation
- Infection
- Mycoplasma hominis
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Cardiothoracic Transplant Recipient Mycoplasma hominis : An Uncommon Infection with Probable Donor Transmission. / Sampath, Rahul; Patel, Robin; Cunningham, Scott A.; Arif, Sana; Daly, Richard C.; Badley, Andrew David; Wylam, Mark.
In: EBioMedicine, Vol. 19, 01.05.2017, p. 84-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiothoracic Transplant Recipient Mycoplasma hominis
T2 - An Uncommon Infection with Probable Donor Transmission
AU - Sampath, Rahul
AU - Patel, Robin
AU - Cunningham, Scott A.
AU - Arif, Sana
AU - Daly, Richard C.
AU - Badley, Andrew David
AU - Wylam, Mark
PY - 2017/5/1
Y1 - 2017/5/1
N2 - The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis. PCR was used to establish the diagnosis in four cases. In two instances, paired single lung transplant recipients manifested infection, and in one of these pairs, isolates were indistinguishable by multilocus sequence typing (MLST). To investigate the prevalence of M. hominis in the lower respiratory tract, we tested 178 bronchoalveolar lavage (BAL) fluids collected from immunocompromised subjects for M. hominis by PCR; all were negative. Review of the literature revealed an additional 15 cases of M. hominis in lung transplant recipients, most with similar clinical presentations to our cases. We recommend that M. hominis should be considered in post-cardiothoracic transplant infections presenting with pleuritis, surgical site infection, or mediastinitis. M. hominis PCR may facilitate early diagnosis and prompt therapy. Evaluation for possible donor transmission should be considered.
AB - The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis. PCR was used to establish the diagnosis in four cases. In two instances, paired single lung transplant recipients manifested infection, and in one of these pairs, isolates were indistinguishable by multilocus sequence typing (MLST). To investigate the prevalence of M. hominis in the lower respiratory tract, we tested 178 bronchoalveolar lavage (BAL) fluids collected from immunocompromised subjects for M. hominis by PCR; all were negative. Review of the literature revealed an additional 15 cases of M. hominis in lung transplant recipients, most with similar clinical presentations to our cases. We recommend that M. hominis should be considered in post-cardiothoracic transplant infections presenting with pleuritis, surgical site infection, or mediastinitis. M. hominis PCR may facilitate early diagnosis and prompt therapy. Evaluation for possible donor transmission should be considered.
KW - Cardiothoracic transplantation
KW - Infection
KW - Mycoplasma hominis
UR - http://www.scopus.com/inward/record.url?scp=85018744532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018744532&partnerID=8YFLogxK
U2 - 10.1016/j.ebiom.2017.04.026
DO - 10.1016/j.ebiom.2017.04.026
M3 - Article
C2 - 28438507
AN - SCOPUS:85018744532
VL - 19
SP - 84
EP - 90
JO - EBioMedicine
JF - EBioMedicine
SN - 2352-3964
ER -