Cardiopoietic index predicts heart repair fitness of patient-derived stem cells

Ruben Crespo-Diaz, Satsuki Yamada, Jozef Bartunek, Carmen M Terzic, Peter De Waele, Sébastien Mauën, Andre Terzic, Atta Behfar

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. Aim: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. Materials & methods: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. Results: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. Conclusion: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.

Original languageEnglish (US)
Pages (from-to)639-649
Number of pages11
JournalBiomarkers in Medicine
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Stem cells
Repair
Stem Cells
Mesenchymal Stromal Cells
Transcription Factors
Cell- and Tissue-Based Therapy
Left Ventricular Function
Coronary Artery Bypass
Regeneration
Heart Diseases
Biomarkers
Population

Keywords

  • cardiopoiesis
  • cardiopoietic stem cells
  • heart failure
  • mesenchymal
  • regenerative medicine
  • stem cells

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

Cite this

Cardiopoietic index predicts heart repair fitness of patient-derived stem cells. / Crespo-Diaz, Ruben; Yamada, Satsuki; Bartunek, Jozef; Terzic, Carmen M; De Waele, Peter; Mauën, Sébastien; Terzic, Andre; Behfar, Atta.

In: Biomarkers in Medicine, Vol. 9, No. 7, 01.07.2015, p. 639-649.

Research output: Contribution to journalArticle

Crespo-Diaz, Ruben ; Yamada, Satsuki ; Bartunek, Jozef ; Terzic, Carmen M ; De Waele, Peter ; Mauën, Sébastien ; Terzic, Andre ; Behfar, Atta. / Cardiopoietic index predicts heart repair fitness of patient-derived stem cells. In: Biomarkers in Medicine. 2015 ; Vol. 9, No. 7. pp. 639-649.
@article{e5a8ce23709042aab963b16beed455fd,
title = "Cardiopoietic index predicts heart repair fitness of patient-derived stem cells",
abstract = "Background: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. Aim: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. Materials & methods: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. Results: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. Conclusion: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.",
keywords = "cardiopoiesis, cardiopoietic stem cells, heart failure, mesenchymal, regenerative medicine, stem cells",
author = "Ruben Crespo-Diaz and Satsuki Yamada and Jozef Bartunek and Terzic, {Carmen M} and {De Waele}, Peter and S{\'e}bastien Mau{\"e}n and Andre Terzic and Atta Behfar",
year = "2015",
month = "7",
day = "1",
doi = "10.2217/bmm.15.31",
language = "English (US)",
volume = "9",
pages = "639--649",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
number = "7",

}

TY - JOUR

T1 - Cardiopoietic index predicts heart repair fitness of patient-derived stem cells

AU - Crespo-Diaz, Ruben

AU - Yamada, Satsuki

AU - Bartunek, Jozef

AU - Terzic, Carmen M

AU - De Waele, Peter

AU - Mauën, Sébastien

AU - Terzic, Andre

AU - Behfar, Atta

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. Aim: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. Materials & methods: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. Results: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. Conclusion: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.

AB - Background: Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice. Aim: To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting. Materials & methods: Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations. Results: While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors. Conclusion: This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.

KW - cardiopoiesis

KW - cardiopoietic stem cells

KW - heart failure

KW - mesenchymal

KW - regenerative medicine

KW - stem cells

UR - http://www.scopus.com/inward/record.url?scp=84946554654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946554654&partnerID=8YFLogxK

U2 - 10.2217/bmm.15.31

DO - 10.2217/bmm.15.31

M3 - Article

C2 - 26014833

AN - SCOPUS:84946554654

VL - 9

SP - 639

EP - 649

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

IS - 7

ER -