Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease

Imran S. Syed, Matthew W. Martinez, Da L. Feng, James Glockner

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Idiopathic hypereosinophilic syndrome (HES) is rare and frequently involves the heart with development of endomyocardial fibrosis, a characteristic restrictive cardiomyopathy. Non-invasive diagnosis is frequently challenging. Recent developments in cardiac magnetic resonance (CMR) imaging techniques offer potential for improved detection and characterization of this entity. We describe the use of contrast-enhanced CMR to demonstrate thrombus, endomyocardial fibrosis and inflammation in eosinophilic endomyocardial disease. A three-layered appearance consisting of normal myocardium, thickened fibrotic endocardium with inflammatory exudate, and overlying thrombus was seen on cine-images. Post-contrast perfusion and delayed enhancement images confirmed the presence and location of endomyocardial fibrosis and thrombus. CMR is an important and powerful addition to current non-invasive diagnostic tools for the clinical diagnosis of eosinophilic endomyocardial disease, and may potentially obviate the need for cardiac biopsy in the future.

Original languageEnglish (US)
JournalInternational Journal of Cardiology
Volume126
Issue number3
DOIs
StatePublished - Jun 6 2008

Fingerprint

Endomyocardial Fibrosis
Thrombosis
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Restrictive Cardiomyopathy
Image Enhancement
Hypereosinophilic Syndrome
Endocardium
Exudates and Transudates
Myocardium
Perfusion
Inflammation
Biopsy

Keywords

  • Endomyocardial fibrosis
  • Hypereosinophilic syndrome
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease. / Syed, Imran S.; Martinez, Matthew W.; Feng, Da L.; Glockner, James.

In: International Journal of Cardiology, Vol. 126, No. 3, 06.06.2008.

Research output: Contribution to journalArticle

Syed, Imran S. ; Martinez, Matthew W. ; Feng, Da L. ; Glockner, James. / Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease. In: International Journal of Cardiology. 2008 ; Vol. 126, No. 3.
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