Cardiac channelopathies and the molecular autopsy

David J. Tester, Michael John Ackerman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter reviews clinical and molecular observations for three potentially lethal arrhythmia syndromes: long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, and Brugada syndrome. It summarizes the role of cardiac channelopathies in sudden infant death syndrome and sudden and unexpected infant deaths; illustrates the role of cardiological assessment of surviving family members and the role of a molecular autopsy in the evaluation of sudden unexplained death and unexplained drowning in the young; and discusses some of the important issues in performing a molecular autopsy, including the benefits of genetic testing, indications for molecular autopsy, the biological material to be used in a molecular autopsy, interpretation of genetic test results, and the legal and societal implications of the molecular autopsy.

Original languageEnglish (US)
Title of host publicationForensic Pathology of Infancy and Childhood
PublisherSpringer New York
Pages899-942
Number of pages44
ISBN (Print)9781617794032, 1617794023, 9781617794025
DOIs
StatePublished - Mar 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Tester, D. J., & Ackerman, M. J. (2014). Cardiac channelopathies and the molecular autopsy. In Forensic Pathology of Infancy and Childhood (pp. 899-942). Springer New York. https://doi.org/10.1007/978-1-61779-403-2_34