Cardiac ATP-sensitive K+ channels: Regulation by intracellular nucleotides and K+ channel-opening drugs

A. Terzic, A. Jahangir, Y. Kurachi

Research output: Contribution to journalReview article

268 Scopus citations

Abstract

ATP-sensitive K+ (K(ATP)) channels are present at high density in membranes of cardiac cells where they regulate cardiac function during cellular metabolic impairment. K(ATP) channels have been implicated in the shortening of the action potential duration and the cellular loss of K+ that occurs during metabolic inhibition. K(ATP) channels have been associated with the cardioprotective mechanism of ischemia-related preconditioning. Intracellular ATP (ATP(i)) is the main regulator of K(ATP) channels. ATP(i) has two functions: 1) to close the channel (ligand function) and 2) in the presence of Mg2+, to maintain the activity of K(ATP) channels (presumably through an enzymatic reaction). K(ATP) channel activity is modulated by intracellular nucleoside diphosphates that antagonize the ATP(i)-induced inhibition of channel opening or induce K(ATP) channels to open. How nucleotides will affect K(ATP) channels depends on the state of the channel. K+ channel-opening drugs are pharmacological agents that enhance K(ATP) channel activity through different mechanisms and have great potential in the management of cardiovascular conditions. K(ATP) channel activity is also modulated by neurohormones. Adenosine, through the activation of a GTP- binding protein, antagonizes the ATP(i)-induced channel closure. Understanding the molecular mechanisms that underlie K(ATP) channel regulation should prove essential to further define the function of K(ATP) channels and to elucidate the pharmacological regulation of this channel protein. Since the molecular structure of the K(ATP) channel has now become available, it is anticipated that major progress in the K(ATP) channel field will be achieved.

Original languageEnglish (US)
Pages (from-to)C525-C545
JournalAmerican Journal of Physiology - Cell Physiology
Volume269
Issue number3 38-3
DOIs
StatePublished - 1995

Keywords

  • adenosine 5'-triphosphate-sensitive potassium channels
  • heart
  • ligand-gated channels
  • nucleotides
  • potassium channel-opening drugs

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Fingerprint Dive into the research topics of 'Cardiac ATP-sensitive K<sup>+</sup> channels: Regulation by intracellular nucleotides and K<sup>+</sup> channel-opening drugs'. Together they form a unique fingerprint.

  • Cite this