Inasmuch as the elevated levels of substance(s) immunologically cross-reactive with insulin (SICRI) in a diabetic woman with carcinoma of the corpus uteri decreased following the surgical removal of the uterus and ovaries, 80 women with cervical carcinomas of various stages and 70 women with carcinomas of the corpus uteri of various stages were screened for the levels of SICRI and C-peptide. The levels of SICRI in the second, third, and fourth stages of the cancers were elevated (up to six times above the normal levels of immunoreactive insulin) and stage-dependent. The levels of C-peptide, which are related to the insulin-secreting activity of pancreatic β-cells, were normal and independent of the stage of cancer.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of the National Cancer Institute|
|State||Published - Oct 11 1982|
ASJC Scopus subject areas
- Cancer Research