Carcinoid heart disease: Diagnosis and management

Sushil A. Luis; Patricia A. Pellikka

doi:10.1016/j.beem.2015.09.005

Carcinoid heart disease: Diagnosis and management

Sushil A. Luis, Patricia A. Pellikka

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Hedinger syndrome refers to carcinoid valvular heart disease. The disease is believed to be triggered by vasoactive substances that result in valvular fibrosis. It classically occurs in patients with metastatic carcinoid and preferentially involves the right sided cardiac valves. Affected valves become thickened and retracted, exhibiting regurgitation and sometimes, stenosis. Echocardiography is recommended in patients with carcinoid syndrome and a follow up study is advisable in those who develop a murmur or other symptoms or signs of valvular heart disease. For appropriately selected patients, valve replacement surgery appears to improve outcomes.

Original language	English (US)
Pages (from-to)	149-158
Number of pages	10
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.beem.2015.09.005
State	Published - Jan 1 2016

Keywords

Hedinger syndrome
carcinoid
echocardiography
valves

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.beem.2015.09.005

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title = "Carcinoid heart disease: Diagnosis and management",

abstract = "Hedinger syndrome refers to carcinoid valvular heart disease. The disease is believed to be triggered by vasoactive substances that result in valvular fibrosis. It classically occurs in patients with metastatic carcinoid and preferentially involves the right sided cardiac valves. Affected valves become thickened and retracted, exhibiting regurgitation and sometimes, stenosis. Echocardiography is recommended in patients with carcinoid syndrome and a follow up study is advisable in those who develop a murmur or other symptoms or signs of valvular heart disease. For appropriately selected patients, valve replacement surgery appears to improve outcomes.",

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T2 - Diagnosis and management

AU - Luis, Sushil A.

AU - Pellikka, Patricia A.

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N2 - Hedinger syndrome refers to carcinoid valvular heart disease. The disease is believed to be triggered by vasoactive substances that result in valvular fibrosis. It classically occurs in patients with metastatic carcinoid and preferentially involves the right sided cardiac valves. Affected valves become thickened and retracted, exhibiting regurgitation and sometimes, stenosis. Echocardiography is recommended in patients with carcinoid syndrome and a follow up study is advisable in those who develop a murmur or other symptoms or signs of valvular heart disease. For appropriately selected patients, valve replacement surgery appears to improve outcomes.

AB - Hedinger syndrome refers to carcinoid valvular heart disease. The disease is believed to be triggered by vasoactive substances that result in valvular fibrosis. It classically occurs in patients with metastatic carcinoid and preferentially involves the right sided cardiac valves. Affected valves become thickened and retracted, exhibiting regurgitation and sometimes, stenosis. Echocardiography is recommended in patients with carcinoid syndrome and a follow up study is advisable in those who develop a murmur or other symptoms or signs of valvular heart disease. For appropriately selected patients, valve replacement surgery appears to improve outcomes.

KW - Hedinger syndrome

KW - carcinoid

KW - echocardiography

KW - valves

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JO - Best Practice and Research: Clinical Endocrinology and Metabolism

JF - Best Practice and Research: Clinical Endocrinology and Metabolism

IS - 1

ER -

Carcinoid heart disease: Diagnosis and management

Abstract

Keywords

ASJC Scopus subject areas

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