Carcinoid Heart Disease

Alain M. Bernheim, Heidi M. Connolly, Timothy J. Hobday, Martin D. Abel, Patricia A. Pellikka

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Carcinoid heart disease is a rare form of valvular heart disease. The management of these patients is complex, as the systemic malignant disease and the cardiac involvement have to be considered at the same time. Progress in the treatment of patients with carcinoid disease has resulted in improved symptom control and survival. Development and progression of carcinoid heart disease are associated with increased morbidity and mortality. In patients with severe cardiac involvement and well-controlled systemic disease, cardiac surgery has been recognized as the only effective treatment option. Valve replacement surgery may not only be beneficial in terms of symptom relief, but may also contribute to the improved survival observed over the past 2 decades in patients with carcinoid heart disease. Early diagnosis and early surgical treatment in appropriately selected patients may provide the best results. In this article, we review the current literature regarding the biology, diagnosis, treatment, and prognosis of carcinoid heart disease.

Original languageEnglish (US)
Pages (from-to)439-451
Number of pages13
JournalProgress in Cardiovascular Diseases
Issue number6
StatePublished - May 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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