TY - JOUR
T1 - Carcinoid Heart Disease
AU - Bernheim, Alain M.
AU - Connolly, Heidi M.
AU - Hobday, Timothy J.
AU - Abel, Martin D.
AU - Pellikka, Patricia A.
N1 - Funding Information:
Dr AM Bernheim was supported by grants from the Swiss National Science Foundation, Zurich, Switzerland, and the Freiwillige Akademische Gesellschaft, Basel, Switzerland.
PY - 2007/5
Y1 - 2007/5
N2 - Carcinoid heart disease is a rare form of valvular heart disease. The management of these patients is complex, as the systemic malignant disease and the cardiac involvement have to be considered at the same time. Progress in the treatment of patients with carcinoid disease has resulted in improved symptom control and survival. Development and progression of carcinoid heart disease are associated with increased morbidity and mortality. In patients with severe cardiac involvement and well-controlled systemic disease, cardiac surgery has been recognized as the only effective treatment option. Valve replacement surgery may not only be beneficial in terms of symptom relief, but may also contribute to the improved survival observed over the past 2 decades in patients with carcinoid heart disease. Early diagnosis and early surgical treatment in appropriately selected patients may provide the best results. In this article, we review the current literature regarding the biology, diagnosis, treatment, and prognosis of carcinoid heart disease.
AB - Carcinoid heart disease is a rare form of valvular heart disease. The management of these patients is complex, as the systemic malignant disease and the cardiac involvement have to be considered at the same time. Progress in the treatment of patients with carcinoid disease has resulted in improved symptom control and survival. Development and progression of carcinoid heart disease are associated with increased morbidity and mortality. In patients with severe cardiac involvement and well-controlled systemic disease, cardiac surgery has been recognized as the only effective treatment option. Valve replacement surgery may not only be beneficial in terms of symptom relief, but may also contribute to the improved survival observed over the past 2 decades in patients with carcinoid heart disease. Early diagnosis and early surgical treatment in appropriately selected patients may provide the best results. In this article, we review the current literature regarding the biology, diagnosis, treatment, and prognosis of carcinoid heart disease.
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U2 - 10.1016/j.pcad.2006.12.002
DO - 10.1016/j.pcad.2006.12.002
M3 - Article
C2 - 17498524
AN - SCOPUS:34247847858
SN - 0033-0620
VL - 49
SP - 439
EP - 451
JO - Progress in Cardiovascular Diseases
JF - Progress in Cardiovascular Diseases
IS - 6
ER -