Capsule Retention in Crohn's Disease: A Meta-analysis

Shabana F. Pasha, Marco Pennazio, Emanuele Rondonotti, Douglas Wolf, Matthew R. Buras, Jörg G. Albert, Stanley A. Cohen, Jose Cotter, Geert D'Haens, Rami Eliakim, David T. Rubin, Jonathan A. Leighton

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn's disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography. METHODS: Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of <0.05. RESULTS: In the overall CD cohort, retention rates were 3.32% (95% confidence interval [CI], 2.62%-4.2%): 4.63% (95% CI, 3.42%-6.25%) and 2.35% (95% CI, 1.31%-4.19%) in ECD and SCD, respectively. Retention rates were 3.49% (95% CI, 2.73%-4.46%) and 1.64% (95% CI, 0.68%-3.89%) in adult and pediatric CD, respectively. Retention risk in adult ECD was 3.4 times higher than SCD, but there was no difference in retention risk in pediatric ECD compared with SCD. Retention rates in ECD were decreased after patency capsule (2.88%; 95% CI, 1.74%-4.74%) and MR/CT enterography (2.32%; 95% CI, 0.87%-6.03%). CONCLUSIONS: In comparison with older literature, this meta-analysis demonstrates lower CE retention rates in SCD and ECD. Retention rates in pediatric CD were lower than in adult CD. Retention rates in adult ECD were higher than SCD, but there were no differences between pediatric ECD and SCD. Retention rates in ECD were lower after negative PC or MR/CT enterography.

Original languageEnglish (US)
Pages (from-to)33-42
Number of pages10
JournalInflammatory bowel diseases
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2020

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Crohn Disease
Capsules
Meta-Analysis
Confidence Intervals
Capsule Endoscopy
Magnetic Resonance Spectroscopy
Tomography
Pediatrics
Pediatric Crohn's disease

Keywords

  • capsule endoscopy
  • Crohn’s disease
  • meta-analysis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

Cite this

Capsule Retention in Crohn's Disease : A Meta-analysis. / Pasha, Shabana F.; Pennazio, Marco; Rondonotti, Emanuele; Wolf, Douglas; Buras, Matthew R.; Albert, Jörg G.; Cohen, Stanley A.; Cotter, Jose; D'Haens, Geert; Eliakim, Rami; Rubin, David T.; Leighton, Jonathan A.

In: Inflammatory bowel diseases, Vol. 26, No. 1, 01.01.2020, p. 33-42.

Research output: Contribution to journalArticle

Pasha, SF, Pennazio, M, Rondonotti, E, Wolf, D, Buras, MR, Albert, JG, Cohen, SA, Cotter, J, D'Haens, G, Eliakim, R, Rubin, DT & Leighton, JA 2020, 'Capsule Retention in Crohn's Disease: A Meta-analysis', Inflammatory bowel diseases, vol. 26, no. 1, pp. 33-42. https://doi.org/10.1093/ibd/izz083
Pasha SF, Pennazio M, Rondonotti E, Wolf D, Buras MR, Albert JG et al. Capsule Retention in Crohn's Disease: A Meta-analysis. Inflammatory bowel diseases. 2020 Jan 1;26(1):33-42. https://doi.org/10.1093/ibd/izz083
Pasha, Shabana F. ; Pennazio, Marco ; Rondonotti, Emanuele ; Wolf, Douglas ; Buras, Matthew R. ; Albert, Jörg G. ; Cohen, Stanley A. ; Cotter, Jose ; D'Haens, Geert ; Eliakim, Rami ; Rubin, David T. ; Leighton, Jonathan A. / Capsule Retention in Crohn's Disease : A Meta-analysis. In: Inflammatory bowel diseases. 2020 ; Vol. 26, No. 1. pp. 33-42.
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abstract = "BACKGROUND: The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn's disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography. METHODS: Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of <0.05. RESULTS: In the overall CD cohort, retention rates were 3.32{\%} (95{\%} confidence interval [CI], 2.62{\%}-4.2{\%}): 4.63{\%} (95{\%} CI, 3.42{\%}-6.25{\%}) and 2.35{\%} (95{\%} CI, 1.31{\%}-4.19{\%}) in ECD and SCD, respectively. Retention rates were 3.49{\%} (95{\%} CI, 2.73{\%}-4.46{\%}) and 1.64{\%} (95{\%} CI, 0.68{\%}-3.89{\%}) in adult and pediatric CD, respectively. Retention risk in adult ECD was 3.4 times higher than SCD, but there was no difference in retention risk in pediatric ECD compared with SCD. Retention rates in ECD were decreased after patency capsule (2.88{\%}; 95{\%} CI, 1.74{\%}-4.74{\%}) and MR/CT enterography (2.32{\%}; 95{\%} CI, 0.87{\%}-6.03{\%}). CONCLUSIONS: In comparison with older literature, this meta-analysis demonstrates lower CE retention rates in SCD and ECD. Retention rates in pediatric CD were lower than in adult CD. Retention rates in adult ECD were higher than SCD, but there were no differences between pediatric ECD and SCD. Retention rates in ECD were lower after negative PC or MR/CT enterography.",
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T2 - A Meta-analysis

AU - Pasha, Shabana F.

AU - Pennazio, Marco

AU - Rondonotti, Emanuele

AU - Wolf, Douglas

AU - Buras, Matthew R.

AU - Albert, Jörg G.

AU - Cohen, Stanley A.

AU - Cotter, Jose

AU - D'Haens, Geert

AU - Eliakim, Rami

AU - Rubin, David T.

AU - Leighton, Jonathan A.

PY - 2020/1/1

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N2 - BACKGROUND: The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn's disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography. METHODS: Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of <0.05. RESULTS: In the overall CD cohort, retention rates were 3.32% (95% confidence interval [CI], 2.62%-4.2%): 4.63% (95% CI, 3.42%-6.25%) and 2.35% (95% CI, 1.31%-4.19%) in ECD and SCD, respectively. Retention rates were 3.49% (95% CI, 2.73%-4.46%) and 1.64% (95% CI, 0.68%-3.89%) in adult and pediatric CD, respectively. Retention risk in adult ECD was 3.4 times higher than SCD, but there was no difference in retention risk in pediatric ECD compared with SCD. Retention rates in ECD were decreased after patency capsule (2.88%; 95% CI, 1.74%-4.74%) and MR/CT enterography (2.32%; 95% CI, 0.87%-6.03%). CONCLUSIONS: In comparison with older literature, this meta-analysis demonstrates lower CE retention rates in SCD and ECD. Retention rates in pediatric CD were lower than in adult CD. Retention rates in adult ECD were higher than SCD, but there were no differences between pediatric ECD and SCD. Retention rates in ECD were lower after negative PC or MR/CT enterography.

AB - BACKGROUND: The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn's disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography. METHODS: Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of <0.05. RESULTS: In the overall CD cohort, retention rates were 3.32% (95% confidence interval [CI], 2.62%-4.2%): 4.63% (95% CI, 3.42%-6.25%) and 2.35% (95% CI, 1.31%-4.19%) in ECD and SCD, respectively. Retention rates were 3.49% (95% CI, 2.73%-4.46%) and 1.64% (95% CI, 0.68%-3.89%) in adult and pediatric CD, respectively. Retention risk in adult ECD was 3.4 times higher than SCD, but there was no difference in retention risk in pediatric ECD compared with SCD. Retention rates in ECD were decreased after patency capsule (2.88%; 95% CI, 1.74%-4.74%) and MR/CT enterography (2.32%; 95% CI, 0.87%-6.03%). CONCLUSIONS: In comparison with older literature, this meta-analysis demonstrates lower CE retention rates in SCD and ECD. Retention rates in pediatric CD were lower than in adult CD. Retention rates in adult ECD were higher than SCD, but there were no differences between pediatric ECD and SCD. Retention rates in ECD were lower after negative PC or MR/CT enterography.

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