Cancer of the pancreas

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Pancreatic cancer (PC) is an uncommon but often rapidly lethal malignancy. Worldwide, PC is the twelfth most commonly diagnosed cancer and the seventh most common for cancer deaths. Globally, the estimated number of incident cases (338,000) and deaths from PC (330,400) were almost identical in 2012 Etiologic research on PC is complicated by the relatively inaccessible location of the pancreas, obstacles to early diagnosis, aggressiveness and resistance to therapy of these malignancies, and the tendency of PC to progress rapidly. Until recently, the only etiologic factors considered to be definite causes of PC were Tobacco use, chronic pancreatitis, and several rare high-penetrance genetic disorders. In the past decade, the evidence for other causal relationships has strengthened, especially for metabolic risk factors (obesity, type II diabetes mellitus, insulin and insulin-like growth factor), chronic local inflammation, heavy alcohol consumption, dietary consumption of grilled meat, and non-O ABO blood type.

Original languageEnglish (US)
Title of host publicationSchottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition
PublisherOxford University Press
Pages611-634
Number of pages24
ISBN (Electronic)9780190238667
DOIs
StatePublished - Jan 1 2017

Fingerprint

Pancreatic Neoplasms
Neoplasms
Inborn Genetic Diseases
Penetrance
Chronic Pancreatitis
Tobacco Use
Somatomedins
Alcohol Drinking
Meat
Type 2 Diabetes Mellitus
Early Diagnosis
Pancreas
Obesity
Insulin
Inflammation
Research

Keywords

  • Etiology
  • Obesity
  • Pancreatic cancer
  • Pancreatitis
  • Risk factors
  • Smoking

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antwi, S., Jansen, R. J., & Petersen, G. M. (2017). Cancer of the pancreas. In Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition (pp. 611-634). Oxford University Press. https://doi.org/10.1093/oso/9780190238667.003.0032

Cancer of the pancreas. / Antwi, Samuel; Jansen, Rick J.; Petersen, Gloria M.

Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press, 2017. p. 611-634.

Research output: Chapter in Book/Report/Conference proceedingChapter

Antwi, S, Jansen, RJ & Petersen, GM 2017, Cancer of the pancreas. in Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press, pp. 611-634. https://doi.org/10.1093/oso/9780190238667.003.0032
Antwi S, Jansen RJ, Petersen GM. Cancer of the pancreas. In Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press. 2017. p. 611-634 https://doi.org/10.1093/oso/9780190238667.003.0032
Antwi, Samuel ; Jansen, Rick J. ; Petersen, Gloria M. / Cancer of the pancreas. Schottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition. Oxford University Press, 2017. pp. 611-634
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