Calcium channel autoimmunity: Cerebellar ataxia and lambert-eaton syndrome coexisting

Nicholas Zalewski, Vanda A Lennon, Sean J Pittock, Andrew B McKeon

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Introduction: Neuronal calcium channel antibodies are a biomarker of Lambert-Eaton syndrome (LES) and cerebellar ataxia. We have encountered several patients with LES and cerebellar ataxia coexisting, and we sought to further define this association. Methods: We reviewed records of patients at our institution with a diagnosis of "Lambert-Eaton syndrome" and "cerebellar ataxia." Results: Seventeen patients were identified with LES and ataxia. Presenting symptoms were weakness (8), concurrent weakness and ataxia (4), ataxia (4), and other (1). Nine patients had small-cell lung carcinoma, 3 of whom had survival greater than 100 months. Immunotherapy responses were best among patients without cancer. Nine of 17 (53%) patients were alive at last follow-up (median survival 62 months; range, 8-240). Discussion: Calcium channel autoimmunity should be considered in patients with coexisting cerebellar ataxia and myasthenic weakness. Affected patients may survive small-cell carcinoma or have immunotherapy-responsive neurological symptoms.

Original languageEnglish (US)
JournalMuscle and Nerve
DOIs
StateAccepted/In press - Jan 1 2018

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Lambert-Eaton Myasthenic Syndrome
Cerebellar Ataxia
Calcium Channels
Autoimmunity
Ataxia
Immunotherapy
Small Cell Carcinoma
Survival
Muscle Weakness
Small Cell Lung Carcinoma
Biomarkers

Keywords

  • Ataxia
  • Calcium channel
  • Lambert-Eaton syndrome
  • Myasthenic syndrome
  • Paraneoplastic
  • Small-cell lung carcinoma

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Calcium channel autoimmunity : Cerebellar ataxia and lambert-eaton syndrome coexisting. / Zalewski, Nicholas; Lennon, Vanda A; Pittock, Sean J; McKeon, Andrew B.

In: Muscle and Nerve, 01.01.2018.

Research output: Contribution to journal › Article

Zalewski, N, Lennon, VA, Pittock, SJ & McKeon, AB 2018, 'Calcium channel autoimmunity: Cerebellar ataxia and lambert-eaton syndrome coexisting', Muscle and Nerve. https://doi.org/10.1002/mus.26053
Zalewski N, Lennon VA, Pittock SJ, McKeon AB. Calcium channel autoimmunity: Cerebellar ataxia and lambert-eaton syndrome coexisting. Muscle and Nerve. 2018 Jan 1. https://doi.org/10.1002/mus.26053
Zalewski, Nicholas ; Lennon, Vanda A ; Pittock, Sean J ; McKeon, Andrew B. / Calcium channel autoimmunity : Cerebellar ataxia and lambert-eaton syndrome coexisting. In: Muscle and Nerve. 2018.
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AU - Pittock, Sean J

AU - McKeon, Andrew B

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N2 - Introduction: Neuronal calcium channel antibodies are a biomarker of Lambert-Eaton syndrome (LES) and cerebellar ataxia. We have encountered several patients with LES and cerebellar ataxia coexisting, and we sought to further define this association. Methods: We reviewed records of patients at our institution with a diagnosis of "Lambert-Eaton syndrome" and "cerebellar ataxia." Results: Seventeen patients were identified with LES and ataxia. Presenting symptoms were weakness (8), concurrent weakness and ataxia (4), ataxia (4), and other (1). Nine patients had small-cell lung carcinoma, 3 of whom had survival greater than 100 months. Immunotherapy responses were best among patients without cancer. Nine of 17 (53%) patients were alive at last follow-up (median survival 62 months; range, 8-240). Discussion: Calcium channel autoimmunity should be considered in patients with coexisting cerebellar ataxia and myasthenic weakness. Affected patients may survive small-cell carcinoma or have immunotherapy-responsive neurological symptoms.

AB - Introduction: Neuronal calcium channel antibodies are a biomarker of Lambert-Eaton syndrome (LES) and cerebellar ataxia. We have encountered several patients with LES and cerebellar ataxia coexisting, and we sought to further define this association. Methods: We reviewed records of patients at our institution with a diagnosis of "Lambert-Eaton syndrome" and "cerebellar ataxia." Results: Seventeen patients were identified with LES and ataxia. Presenting symptoms were weakness (8), concurrent weakness and ataxia (4), ataxia (4), and other (1). Nine patients had small-cell lung carcinoma, 3 of whom had survival greater than 100 months. Immunotherapy responses were best among patients without cancer. Nine of 17 (53%) patients were alive at last follow-up (median survival 62 months; range, 8-240). Discussion: Calcium channel autoimmunity should be considered in patients with coexisting cerebellar ataxia and myasthenic weakness. Affected patients may survive small-cell carcinoma or have immunotherapy-responsive neurological symptoms.

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KW - Myasthenic syndrome

KW - Paraneoplastic

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