Bronchocentric mycosis occurring in transplant recipients

H. D. Tazelaar, A. M. Baird, M. Mill, M. M. Grimes, L. L. Schulman, C. R. Smith

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Although a variety of long-term, probably immunologically induced pulmonary changes have been described in recipients of both combined heart-lung and bone marrow transplantation, pulmonary infections continue to remain causes of significant morbidity and mortality as well. Herein we describe three patients (two heart-lung and one bone marrow transplant recipient) who had bronchocentric granulomatous mycosis, a tissue manifestation of fungal infection not previously described in the setting of a transplant host. Although one patient was being treated successfully with antifungal agents for his mucormycosis, two other patients eventually died of invasive aspergillosis. This emphasizes that although this process is histologically somewhat similar to bronchocentric granulomatosis, a high index of suspicion for infection needs to be maintained when this pathologic process is identified in a transplant host.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalChest
Volume96
Issue number1
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Tazelaar, H. D., Baird, A. M., Mill, M., Grimes, M. M., Schulman, L. L., & Smith, C. R. (1989). Bronchocentric mycosis occurring in transplant recipients. Chest, 96(1), 92-95. https://doi.org/10.1378/chest.96.1.92