Bridging from multiscale modeling to practical clinical applications in the study of human gliomas

Gargi Chakraborty, Rita Sodt, Susan Massey, Stanley Gu, Russell Rockne, Ellsworth C. Alvord, Kristin R. Swanson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gliomas are malignant lesions of the brain characterized by their propensity to proliferate and invade the normal-appearing tissue. These brain tumors show diverse anatomic and metabolic traits that manifest differently across patients, ranging in aggressiveness from low-grade gliomas (LGGs) to high-grade gliomas (HGGs). Approximately 50% of glioma patients are diagnosed with glioblastoma multiforme (GBM), a World Health Organization grade IV glioma, which is the most aggressive type of brain tumor in adults (Louis et al. 2007). Difficulty in treating gliomas arises primarily from the invasiveness of the cell populations comprising the tumor. Despite extensive treatments including surgical resection, radiotherapy, and chemotherapy, GBMs have a propensity to recur and prove to be fatal with a median survival of approximately 1 year (Burnet et al. 2007; Welsh et al. 2009).

Original languageEnglish (US)
Title of host publicationMultiscale Cancer Modeling
PublisherCRC Press
Pages359-375
Number of pages17
ISBN (Electronic)9781439814420
ISBN (Print)9781439814406
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Mathematics(all)
  • Physics and Astronomy(all)
  • Medicine(all)

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