Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Joanne Kotsopoulos; Jan Lubinski; Leonardo Salmena; Henry T. Lynch; Charmaine Kim-Sing; William D. Foulkes; Parviz Ghadirian; Susan L. Neuhausen; Rochelle Demsky; Nadine Tung; Peter Ainsworth; Leigha Senter; Andrea Eisen; Charis Eng; Christian Singer; Ophira Ginsburg; Joanne Blum; Tomasz Huzarski; Aletta Poll; Ping Sun; Steven A. Narod; Mary Daly; Dawna Gilchrist; Taya Fallen; Albert Chudley; John Lunn; Talia Donenberg; Beth Karlan; Raluca N. Kurz; Jeffrey Weitzel; Howard Saal; Dana Zakalik; Susan Friedman; Judy Garber; Gad Rennert; Kevin Sweet; Ruth Gershoni-Baruch; Christine Rappaport; Edmond Lemire; Dominique Stoppa-Lyonnet; Olufunmilayo I. Olopade; Sofia Merajver; Louise Bordeleau; Carey A. Cullinane; Eitan Friedman; Wendy McKinnon; Marie Wood; Daniel Rayson; Wendy Meschino; Jane McLennan; Josephine Wagner Costalas; Robert E. Reilly; Tuya Pal; Susan Vadaparampil; Kenneth Offit; Mark Robson; Noah Kauff; Jan Klijn; Pal Moller; David Euhus; Ava Kwong; Claudine Isaacs; Fergus Couch; Siranoush Manoukian; Cezary Cybulski; Jacek Gronwald; Tomasz Byrski; Seema Panchal; Sonia Nanda; Kelly Metcalfe; Barry Rosen; Susan Randall; Adriana Valentini; Marcia Llacuachaqui; Alejandra Ragone; Jennifer Ng; Kristi De Buono; Kate Bisnaire; Dina Nikitina; Anneli Loo; Bita Khorram; Dina Gordon; Courtney May; Michelle Jones; Jose Miguel Lozano

doi:10.1186/bcr3138

Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Joanne Kotsopoulos, Jan Lubinski, Leonardo Salmena, Henry T. Lynch, Charmaine Kim-Sing, William D. Foulkes, Parviz Ghadirian, Susan L. Neuhausen, Rochelle Demsky, Nadine Tung, Peter Ainsworth, Leigha Senter, Andrea Eisen, Charis Eng, Christian Singer, Ophira Ginsburg, Joanne Blum, Tomasz Huzarski, Aletta Poll, Ping SunSteven A. Narod, Mary Daly, Dawna Gilchrist, Taya Fallen, Albert Chudley, John Lunn, Talia Donenberg, Beth Karlan, Raluca N. Kurz, Jeffrey Weitzel, Howard Saal, Dana Zakalik, Susan Friedman, Judy Garber, Gad Rennert, Kevin Sweet, Ruth Gershoni-Baruch, Christine Rappaport, Edmond Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofia Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy Meschino, Jane McLennan, Josephine Wagner Costalas, Robert E. Reilly, Tuya Pal, Susan Vadaparampil, Kenneth Offit, Mark Robson, Noah Kauff, Jan Klijn, Pal Moller, David Euhus, Ava Kwong, Claudine Isaacs, Fergus Couch, Siranoush Manoukian, Cezary Cybulski, Jacek Gronwald, Tomasz Byrski, Seema Panchal, Sonia Nanda, Kelly Metcalfe, Barry Rosen, Susan Randall, Adriana Valentini, Marcia Llacuachaqui, Alejandra Ragone, Jennifer Ng, Kristi De Buono, Kate Bisnaire, Dina Nikitina, Anneli Loo, Bita Khorram, Dina Gordon, Courtney May, Michelle Jones, Jose Miguel Lozano

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.

Original language	English (US)
Article number	R42
Journal	Breast Cancer Research
Volume	14
Issue number	2
DOIs	https://doi.org/10.1186/bcr3138
State	Published - Mar 9 2012

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1186/bcr3138

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Kotsopoulos, J., Lubinski, J., Salmena, L., Lynch, H. T., Kim-Sing, C., Foulkes, W. D., Ghadirian, P., Neuhausen, S. L., Demsky, R., Tung, N., Ainsworth, P., Senter, L., Eisen, A., Eng, C., Singer, C., Ginsburg, O., Blum, J., Huzarski, T., Poll, A., ... Lozano, J. M. (2012). Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research, 14(2), Article R42. https://doi.org/10.1186/bcr3138

Kotsopoulos, J, Lubinski, J, Salmena, L, Lynch, HT, Kim-Sing, C, Foulkes, WD, Ghadirian, P, Neuhausen, SL, Demsky, R, Tung, N, Ainsworth, P, Senter, L, Eisen, A, Eng, C, Singer, C, Ginsburg, O, Blum, J, Huzarski, T, Poll, A, Sun, P, Narod, SA, Daly, M, Gilchrist, D, Fallen, T, Chudley, A, Lunn, J, Donenberg, T, Karlan, B, Kurz, RN, Weitzel, J, Saal, H, Zakalik, D, Friedman, S, Garber, J, Rennert, G, Sweet, K, Gershoni-Baruch, R, Rappaport, C, Lemire, E, Stoppa-Lyonnet, D, Olopade, OI, Merajver, S, Bordeleau, L, Cullinane, CA, Friedman, E, McKinnon, W, Wood, M, Rayson, D, Meschino, W, McLennan, J, Costalas, JW, Reilly, RE, Pal, T, Vadaparampil, S, Offit, K, Robson, M, Kauff, N, Klijn, J, Moller, P, Euhus, D, Kwong, A, Isaacs, C, Couch, F, Manoukian, S, Cybulski, C, Gronwald, J, Byrski, T, Panchal, S, Nanda, S, Metcalfe, K, Rosen, B, Randall, S, Valentini, A, Llacuachaqui, M, Ragone, A, Ng, J, Buono, KD, Bisnaire, K, Nikitina, D, Loo, A, Khorram, B, Gordon, D, May, C, Jones, M & Lozano, JM 2012, 'Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers', Breast Cancer Research, vol. 14, no. 2, R42. https://doi.org/10.1186/bcr3138

@article{5fa78c7794634e3fb14bc6dfe138da99,

title = "Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers",

abstract = "Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.",

author = "Joanne Kotsopoulos and Jan Lubinski and Leonardo Salmena and Lynch, {Henry T.} and Charmaine Kim-Sing and Foulkes, {William D.} and Parviz Ghadirian and Neuhausen, {Susan L.} and Rochelle Demsky and Nadine Tung and Peter Ainsworth and Leigha Senter and Andrea Eisen and Charis Eng and Christian Singer and Ophira Ginsburg and Joanne Blum and Tomasz Huzarski and Aletta Poll and Ping Sun and Narod, {Steven A.} and Mary Daly and Dawna Gilchrist and Taya Fallen and Albert Chudley and John Lunn and Talia Donenberg and Beth Karlan and Kurz, {Raluca N.} and Jeffrey Weitzel and Howard Saal and Dana Zakalik and Susan Friedman and Judy Garber and Gad Rennert and Kevin Sweet and Ruth Gershoni-Baruch and Christine Rappaport and Edmond Lemire and Dominique Stoppa-Lyonnet and Olopade, {Olufunmilayo I.} and Sofia Merajver and Louise Bordeleau and Cullinane, {Carey A.} and Eitan Friedman and Wendy McKinnon and Marie Wood and Daniel Rayson and Wendy Meschino and Jane McLennan and Costalas, {Josephine Wagner} and Reilly, {Robert E.} and Tuya Pal and Susan Vadaparampil and Kenneth Offit and Mark Robson and Noah Kauff and Jan Klijn and Pal Moller and David Euhus and Ava Kwong and Claudine Isaacs and Fergus Couch and Siranoush Manoukian and Cezary Cybulski and Jacek Gronwald and Tomasz Byrski and Seema Panchal and Sonia Nanda and Kelly Metcalfe and Barry Rosen and Susan Randall and Adriana Valentini and Marcia Llacuachaqui and Alejandra Ragone and Jennifer Ng and Buono, {Kristi De} and Kate Bisnaire and Dina Nikitina and Anneli Loo and Bita Khorram and Dina Gordon and Courtney May and Michelle Jones and Lozano, {Jose Miguel}",

note = "Funding Information: We would like to acknowledge other members of the Hereditary Breast Cancer Clinical Study Group who contributed to the study: Mary Daly, Dawna Gilchrist, Taya Fallen, Albert Chudley, John Lunn, Talia Donenberg, Beth Karlan, Raluca N. Kurz, Jeffrey Weitzel, Howard Saal, Dana Zakalik, Susan Friedman (on behalf of FORCE), Judy Garber, Gad Rennert, Kevin Sweet, Ruth Gershoni-Baruch, Christine Rappaport, Edmond Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofia Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy Meschino, Jane McLennan, Josephine Wagner Costalas, Robert E. Reilly, Tuya Pal, Susan Vadaparampil, Kenneth Offit, Mark Robson, Noah Kauff, Jan Klijn, Pal Moller, David Euhus, Ava Kwong, Claudine Isaacs, Fergus Couch, Siranoush Manoukian, Cezary Cybulski, Jacek Gronwald, Tomasz Byrski, Seema Panchal, Sonia Nanda, Kelly Metcalfe, Barry Rosen and Susan Randall. We would also like to acknowledge the study coordinators Adriana Valentini, Marcia Llacuachaqui and Alejandra Ragone, as well as the students and staff (Jennifer Ng, Kristi De Buono, Kate Bisnaire, Dina Nikitina, Anneli Loo, Bita Khorram, Dina Gordon, Courtney May, Michelle Jones and Jose Miguel Lozano), who helped with the data collection and data entry. Joanne Kotsopoulos is the recipient of a Cancer Care Ontario Research Chair in Population Studies. Charis Eng is the recipient of the Sondra J. and Stephen R. Hardis Chair of Cancer Genomic Medicine at the Cleveland Clinic and of the ACS Clinical Research Professorship. Susan L. Neuhausen is partially supported by the Morris and Horowitz Endowed Professorship and her work was supported by a grant from the NIH, R01CA74415. Steven Narod is the recipient of a Canada Research Chair tier I.",

year = "2012",

month = mar,

day = "9",

doi = "10.1186/bcr3138",

language = "English (US)",

volume = "14",

journal = "Breast Cancer Research",

issn = "1465-5411",

publisher = "BioMed Central",

number = "2",

}

TY - JOUR

T1 - Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

AU - Kotsopoulos, Joanne

AU - Lubinski, Jan

AU - Salmena, Leonardo

AU - Lynch, Henry T.

AU - Kim-Sing, Charmaine

AU - Foulkes, William D.

AU - Ghadirian, Parviz

AU - Neuhausen, Susan L.

AU - Demsky, Rochelle

AU - Tung, Nadine

AU - Ainsworth, Peter

AU - Senter, Leigha

AU - Eisen, Andrea

AU - Eng, Charis

AU - Singer, Christian

AU - Ginsburg, Ophira

AU - Blum, Joanne

AU - Huzarski, Tomasz

AU - Poll, Aletta

AU - Sun, Ping

AU - Narod, Steven A.

AU - Daly, Mary

AU - Gilchrist, Dawna

AU - Fallen, Taya

AU - Chudley, Albert

AU - Lunn, John

AU - Donenberg, Talia

AU - Karlan, Beth

AU - Kurz, Raluca N.

AU - Weitzel, Jeffrey

AU - Saal, Howard

AU - Zakalik, Dana

AU - Friedman, Susan

AU - Garber, Judy

AU - Rennert, Gad

AU - Sweet, Kevin

AU - Gershoni-Baruch, Ruth

AU - Rappaport, Christine

AU - Lemire, Edmond

AU - Stoppa-Lyonnet, Dominique

AU - Olopade, Olufunmilayo I.

AU - Merajver, Sofia

AU - Bordeleau, Louise

AU - Cullinane, Carey A.

AU - Friedman, Eitan

AU - McKinnon, Wendy

AU - Wood, Marie

AU - Rayson, Daniel

AU - Meschino, Wendy

AU - McLennan, Jane

AU - Costalas, Josephine Wagner

AU - Reilly, Robert E.

AU - Pal, Tuya

AU - Vadaparampil, Susan

AU - Offit, Kenneth

AU - Robson, Mark

AU - Kauff, Noah

AU - Klijn, Jan

AU - Moller, Pal

AU - Euhus, David

AU - Kwong, Ava

AU - Isaacs, Claudine

AU - Couch, Fergus

AU - Manoukian, Siranoush

AU - Cybulski, Cezary

AU - Gronwald, Jacek

AU - Byrski, Tomasz

AU - Panchal, Seema

AU - Nanda, Sonia

AU - Metcalfe, Kelly

AU - Rosen, Barry

AU - Randall, Susan

AU - Valentini, Adriana

AU - Llacuachaqui, Marcia

AU - Ragone, Alejandra

AU - Ng, Jennifer

AU - Buono, Kristi De

AU - Bisnaire, Kate

AU - Nikitina, Dina

AU - Loo, Anneli

AU - Khorram, Bita

AU - Gordon, Dina

AU - May, Courtney

AU - Jones, Michelle

AU - Lozano, Jose Miguel

N1 - Funding Information: We would like to acknowledge other members of the Hereditary Breast Cancer Clinical Study Group who contributed to the study: Mary Daly, Dawna Gilchrist, Taya Fallen, Albert Chudley, John Lunn, Talia Donenberg, Beth Karlan, Raluca N. Kurz, Jeffrey Weitzel, Howard Saal, Dana Zakalik, Susan Friedman (on behalf of FORCE), Judy Garber, Gad Rennert, Kevin Sweet, Ruth Gershoni-Baruch, Christine Rappaport, Edmond Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofia Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy Meschino, Jane McLennan, Josephine Wagner Costalas, Robert E. Reilly, Tuya Pal, Susan Vadaparampil, Kenneth Offit, Mark Robson, Noah Kauff, Jan Klijn, Pal Moller, David Euhus, Ava Kwong, Claudine Isaacs, Fergus Couch, Siranoush Manoukian, Cezary Cybulski, Jacek Gronwald, Tomasz Byrski, Seema Panchal, Sonia Nanda, Kelly Metcalfe, Barry Rosen and Susan Randall. We would also like to acknowledge the study coordinators Adriana Valentini, Marcia Llacuachaqui and Alejandra Ragone, as well as the students and staff (Jennifer Ng, Kristi De Buono, Kate Bisnaire, Dina Nikitina, Anneli Loo, Bita Khorram, Dina Gordon, Courtney May, Michelle Jones and Jose Miguel Lozano), who helped with the data collection and data entry. Joanne Kotsopoulos is the recipient of a Cancer Care Ontario Research Chair in Population Studies. Charis Eng is the recipient of the Sondra J. and Stephen R. Hardis Chair of Cancer Genomic Medicine at the Cleveland Clinic and of the ACS Clinical Research Professorship. Susan L. Neuhausen is partially supported by the Morris and Horowitz Endowed Professorship and her work was supported by a grant from the NIH, R01CA74415. Steven Narod is the recipient of a Canada Research Chair tier I.

PY - 2012/3/9

Y1 - 2012/3/9

N2 - Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.

AB - Introduction: Breastfeeding has been inversely related to breast cancer risk in the general population. Clarifying the role of breastfeeding among women with a BRCA1 or BRCA2 mutation may be helpful for risk assessment and for recommendations regarding prevention. We present an updated analysis of breastfeeding and risk of breast cancer using a large matched sample of BRCA mutation carriers.Methods: We conducted a case-control study of 1,665 pairs of women with a deleterious mutation in either BRCA1 (n = 1,243 pairs) or BRCA2 (n = 422 pairs). Breast cancer cases and unaffected controls were matched on year of birth, mutation status, country of residence and parity. Information about reproductive factors, including breastfeeding for each live birth, was collected from a routinely administered questionnaire. Conditional logistic regression was used to estimate the association between ever having breastfed, as well as total duration of breastfeeding, and the risk of breast cancer.Results: Among BRCA1 mutation carriers, breastfeeding for at least one year was associated with a 32% reduction in risk (OR = 0.68; 95% CI 0.52 to 0.91; P = 0.008); breastfeeding for two or more years conferred a greater reduction in risk (OR = 0.51; 95% CI 0.35 to 0.74). Among BRCA2 mutation carriers, there was no significant association between breastfeeding for at least one year and breast cancer risk (OR = 0.83; 95% CI 0.53 to 1.31; P = 0.43).Conclusions: These data extend our previous findings that breastfeeding protects against BRCA1-, but not BRCA2-associated breast cancer. BRCA mutation carriers should be advised of the benefit of breastfeeding in terms of reducing breast cancer risk.

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U2 - 10.1186/bcr3138

DO - 10.1186/bcr3138

M3 - Article

C2 - 22405187

AN - SCOPUS:84859340313

SN - 1465-5411

VL - 14

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 2

M1 - R42

ER -

Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

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