Botulinum toxin in the treatment of myofascial pain syndrome

William P. Cheshire, Sandra W. Abashian, J. Douglas Mann

Research output: Contribution to journalArticle

286 Citations (Scopus)

Abstract

Six patients with chronic myofascial pain syndrome involving cervical paraspinal and shoulder girdle muscles received trigger point injections of botulinum toxin type A (Botox) or saline in a randomized, double-blind, placebo-controlled study. Four patients experienced reduction in pain of at least 30% following Botox, but not saline, injections, as measured by visual analog scales, verbal descriptors for pain intensity and unpleasantness, palpable muscle firmness, and pressure pain thresholds. Results were statistically significant. Botox, which inhibits muscle contraction by blocking the release of acetylcholine from peripheral nerves, appears to be an effective treatment for focal myofascial pain disorders.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalPain
Volume59
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Myofascial Pain Syndromes
Botulinum Toxins
Trigger Points
Pain
Muscles
Somatoform Disorders
Type A Botulinum Toxins
Injections
Pain Threshold
Muscle Contraction
Visual Analog Scale
Peripheral Nerves
Chronic Pain
Acetylcholine
Therapeutics
Placebos
Pressure
onabotulinumtoxinA

Keywords

  • Botulinum toxin
  • Myofascial pain syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

Cite this

Cheshire, W. P., Abashian, S. W., & Mann, J. D. (1994). Botulinum toxin in the treatment of myofascial pain syndrome. Pain, 59(1), 65-69. https://doi.org/10.1016/0304-3959(94)90048-5

Botulinum toxin in the treatment of myofascial pain syndrome. / Cheshire, William P.; Abashian, Sandra W.; Mann, J. Douglas.

In: Pain, Vol. 59, No. 1, 1994, p. 65-69.

Research output: Contribution to journalArticle

Cheshire, WP, Abashian, SW & Mann, JD 1994, 'Botulinum toxin in the treatment of myofascial pain syndrome', Pain, vol. 59, no. 1, pp. 65-69. https://doi.org/10.1016/0304-3959(94)90048-5
Cheshire, William P. ; Abashian, Sandra W. ; Mann, J. Douglas. / Botulinum toxin in the treatment of myofascial pain syndrome. In: Pain. 1994 ; Vol. 59, No. 1. pp. 65-69.
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