Bone marrow plasma cells 20% or greater discriminate presentation, response, and survival in AL amyloidosis

Eli Muchtar, Morie A. Gertz, Taxiarchis V. Kourelis, Surbhi Sidana, Ronald S. Go, Martha Q. Lacy, Francis K. Buadi, David Dingli, Suzanne R. Hayman, Prashant Kapoor, Nelson Leung, Amie Fonder, Miriam Hobbs, Yi Lisa Hwa, Wilson Gonsalves, Rahma Warsame, Stephen Russell, John A. Lust, Yi Lin, Steven ZeldenrustS. Vincent Rajkumar, Robert A. Kyle, Shaji K. Kumar, Angela Dispenzieri

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We explored the association between bone marrow plasma cells (BMPCs) and disease presentation and outcome among 1574 AL patients. Three BMPC groups were formulated: <5% (n = 231, 15% of study population), 5–19% (n = 1045, 66%), and ≥20% (n = 298, 19%). Heart and renal involvement were more and less prevalent, respectively, with increasing BMPCs. Patients with ≥20% BMPCs had higher likelihood for classic myeloma phenotype with less skewed lambda restriction, a higher rate of intact immunoglobulin secretion, a lower hemoglobin and higher rates of hypercalcemia and bone lytic lesions. High-risk cytogenetic abnormalities were more common in ≥20% BMPCs. Complete hematological response was less frequent with rising BMPCs. The median survival was inversely associated with the BMPC groups (81, 33, 12 months for <5%, 5–19%, and ≥20% BMPCs, respectively; P < 0.001). Survival discrimination was maintained at 1-year landmark and in those who achieved a complete response. Multivariate analysis accounting for known prognostic markers yielded an independent prognostic role for ≥20% BMPCs, but not for the other BMPC groups. AL patients with 20% or greater BMPCs have poorer outcome independent of their cardiac risk category and stem cell transplant eligibility. Distinct interventions in these patients should be explored to improve outcome.

Original languageEnglish (US)
Pages (from-to)1135-1143
Number of pages9
JournalLeukemia
Volume34
Issue number4
DOIs
StatePublished - Apr 2020

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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