Bone marrow in children with acute lymphocytic leukemia: MR relaxation times

S. G. Moore, C. A. Gooding, R. C. Brasch, R. L. Ehman, H. G. Ringertz, A. R. Ablin, K. K. Matthay, S. Zoger

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Magnetic resonance imaging of the lumbar spine was performed in 17 children with acute lymphocytic leukemia (ALL): eight with newly diagnosed ALL, four with ALL in relapse, and five with ALL in remission. Eleven age-matched children were also imaged as controls. The T1 and T2 relaxation times of the bone marrow in the lumbar spine were calculated for all the children. The T1 relaxation times of the bone marrow were as follows (mean ± standard deviation): newly diagnosed ALL, 968 msec ± 68; ALL in relapse, 765 msec ± 19; ALL in remission, 404 msec ± 135; and age-matched controls, 441 msec ± 82. T1 relaxation time was statistically significant in differentiating children with newly diagnosed ALL from normal children and from children with ALL in remission. In addition, T1 may be useful in differentiating children with ALL in relapse from children with ALL in remission and from healthy children. T2 was not significantly different among the four groups.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalRadiology
Volume160
Issue number1
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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